283601-58-1
283601-58-1
Chemical Structure
Docosahexaenoyl serotonin
Synonym(s): DHA-5-HT
- CAS No.: 283601-58-1
- Formula:C32H42N2O2
- Molecular Weight:486.69
IUPAC Name: (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)docosa-4,7,10,13,16,19-hexaenamide
InChIKey: PRXMZJYZMPHWIP-KUBAVDMBSA-N
SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
Biological Activity: Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Docosahexaenoyl serotonin | 99.0% | Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity. | ||||||||||||||||||||
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References
- [1]. Poland M, et al. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028. [Content Brief]
- [2]. Wang Y, Balvers MGJ, Hendriks HFJ, Wilpshaar T, van Heek T, Witkamp RF, Meijerink J. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):823-831. [Content Brief]
Keywords
