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  4. Palmitoyl serotonin

Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD).

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Palmitoyl serotonin Chemical Structure

Palmitoyl serotonin Chemical Structure

CAS No. : 212707-51-2

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Palmitoyl serotonin Related Antibodies

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Description

Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD)[1][2].

In Vivo

Palmitoyl serotonin (0.3 mg/kg; daily for 10 days) effectively attenuates the development of L-DOPA-induced dyskinesia (LID) and increases of ERK1/2 phosphorylation and FosB/ΔFosB expression in the hemi-parkinsonian mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25-28 g, Eight-week-old male C57BL/6J mice ( 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian mouse model)[1]
Dosage: 0.3 mg/kg
Administration: daily for 10 days
Result: Reduced axial, limb, and locomotive AIM scores on day 10, suppressed the hyper-phosphorylation of ERK1/2 in the 6-OHDA-lesioned striatum, suppressed the overexpression of FosB and ΔFosB in the 6-OHDA-lesioned striatum.
Molecular Weight

414.62

Formula

C26H42N2O2
CAS No.
SMILES

CCCCCCCCCCCCCCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
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References
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Palmitoyl serotonin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitoyl serotonin212707-51-2PA-5HTOthersdyskinesiaERK1/2 phosphorylationFosB/ΔFosBparkinson's diseaseInhibitorinhibitorinhibit

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