2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Angiotensin-converting Enzyme (ACE)
  4. Diminazene aceturate

Diminazene aceturate  (Synonyms: Diminazene diaceturate)

Cat. No.: HY-12404 Purity: 99.39%
COA
SDS
Handling Instructions Technical Support

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.

For research use only. We do not sell to patients.

CAS No. : 908-54-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Diminazene aceturate:

Diminazene aceturate Related Antibodies

Top Publications Citing Use of Products

    Diminazene aceturate purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016(25)06272-8.  [Abstract]

    Diminazene aceturate (DIZE; 15 mg/kg; SC）showed a near depletion of Ki-67+ regenerating intestinal crypts. WAG/RijCmcr rats were exposed to 12.5 Gy PBI and treated subcutaneously with vehicle or Diminazene aceturate (DIZE; 15 mg/kg; SC on days 3, 4, and 5 postirradiation. Representative Ki-67-stained IHC cross-sections of day 6 jejunum from nonirradiated, 12.5 Gy + vehicle-treated, or 12.5 Gy + DIZE.

    Diminazene aceturate purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016(25)06272-8.  [Abstract]

    Diminazene aceturate (DIZE; 15 mg/kg; SC）showed a decrease in plasma citrulline levels indicative of reduced GI mass in WAG/RijCmcr rats. Mean plasma citrulline levels at day 6 in female and male rats after irradiation and treatment with vehicle or DIZE.

    Diminazene aceturate purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016(25)06272-8.  [Abstract]

    Diminazene aceturate (DIZE; 15 mg/kg; SC) increased luminal ACE2 staining. Representative ACE2-stained IHC cross-sections of day 6 jejunums from nonirradiated, 12.5 Gy + vehicle-treated, or 12.5 Gy + DIZE.

    Diminazene aceturate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2022 Mar 1;34(3):424-440.e7.  [Abstract]

    The direct binding was illustrated by surface plasmon resonance (SPR) assay of purified ACE2 protein with Diminazene aceturate (DIZE;0.125, 0.25, 0.5, 1, 2 μM).

    Diminazene aceturate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2022 Mar 1;34(3):424-440.e7.  [Abstract]

    HUVECs were treated with Diminazene aceturate (DIZE, 100 μM), imatinib (Ima), harpagoside (Har) or methazolamide (Met) for 16 h and subjected to real-time PCR

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    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].

    IC50 & Target

    Trypanosoma

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 CC50
    38.5 μM
    Compound: Diminazene aceturate
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by resazurin assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by resazurin assay
    		[PMID: 33479668]
    In Vitro

    Pre-treatment of bone marrow-derived macrophages (BMDM) and dendritic cells (BMDC) with Diminazene aceturate (Berenil) downregulats LPS-, CpG- and Poly I:C-induced proinflammatory cytokine production, suggesting that it may be affecting common pathways through which these molecules stimulate proinflammatory cytokine production. Indeed, Diminazene aceturate does not alter the expression of different TLRs (including TLR2, TLR4 and TLR9), on macrophages and DCs when assessed by flow cytometry. Instead, Diminazene aceturate dramatically downregulats the phosphorylation of MAPKs (ERK, p38 and JNK), STATs (STAT1 and STAT3) and NFκB p65 subunit, which are key signaling molecules and transcription factors involved in the production of proinflammatory cytokines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Diminazene aceturate Related Antibodies
    In Vivo

    Diminazene aceturate (14 mg/kg; intraperitoneal injection; female BALB/c mice and C57BL/6 mice) treatment significantly reduces the percentages of CD25+ cells, a concomitant reduction in the percentage of regulatory (CD4+Foxp3+) T cells and a striking reduction in serum levels of disease exacerbating pro-inflammatory cytokines including IL-6, IL-12, TNF and IFN-γ[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/c mice and C57BL/6 mice (6-8 week old) infected with T. congolense variant antigenic type TC1[1]
    Dosage: 14 mg/kg
    Administration: Intraperitoneal injection
    Result: Significantly reduced the percentages of CD25+ cells, a concomitant reduction in the percentage of regulatory (CD4+Foxp3+) T cells and a striking reduction in serum levels of disease exacerbating pro-inflammatory cytokines including IL-6, IL-12, TNF and IFN-γ.
    Molecular Weight

    515.52

    Formula

    C22H29N9O6
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(O)CNC(C)=O.N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(O)CNC(C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (96.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9398 mL 9.6989 mL 19.3979 mL
    5 mM 0.3880 mL 1.9398 mL 3.8796 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.39%

    SDS (393 KB)

    COA (251 KB) HNMR (282 KB) RP-HPLC (257 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.9398 mL 9.6989 mL 19.3979 mL 48.4947 mL
    5 mM 0.3880 mL 1.9398 mL 3.8796 mL 9.6989 mL
    10 mM 0.1940 mL 0.9699 mL 1.9398 mL 4.8495 mL
    15 mM 0.1293 mL 0.6466 mL 1.2932 mL 3.2330 mL
    20 mM 0.0970 mL 0.4849 mL 0.9699 mL 2.4247 mL
    25 mM 0.0776 mL 0.3880 mL 0.7759 mL 1.9398 mL
    30 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6165 mL
    40 mM 0.0485 mL 0.2425 mL 0.4849 mL 1.2124 mL
    50 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
    60 mM 0.0323 mL 0.1616 mL 0.3233 mL 0.8082 mL
    80 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6062 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Diminazene aceturate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Diminazene908-54-3Diminazene diaceturateParasiteAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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