2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
  4. Talfirastide acetate

Talfirastide acetate  (Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate)

Cat. No.: HY-12403A Purity: 99.76%
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Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.

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CAS No. : 2855063-75-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 17 publication(s) in Google Scholar

Other Forms of Talfirastide acetate:

Talfirastide acetate Related Antibodies

Top Publications Citing Use of Products

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Ang-(1–7) (Talfirastide, 10−6 mol/L, 24 h) regulates the polarization of macrophages towards the M2 phenotype. Double-staining for F4/80 (green)/iNOS (red) or F4/80 (green)/Arg-1 (red) in each group of macrophages (scale bar: 50 μm, n = 5).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    (Talfirastide, 10−6 mol/L). Representative immunoblots and quantification of macrophages in each group showing the expression of iNOS and Arg-1 after treatment for 24 h (n = 3).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Talfirastide (10−6 mol/L, 24h). The ratio of M1 macrophage phenotype-related surface markers, CD86/CD11b, were determined by flow cytometry for each group (n = 3).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Talfirastide (10−6 mol/L, 24h). The ratio of M2 macrophage phenotype-related surface markers, CD206/ CD11b, were determined by flow cytometry for each group (n = 3).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Ang-(1–7) (Talfirastide, 10−6 mol/L, 24h) inhibits inflammation response by modulating the expression of inflammatory cytokines in BMDMs. Quantitative RT-qPCR analysis of macrophages showing mRNA expression of IL-1β, TNF-α, IL-10, IL-4 after treatment for 24 h. GAPDH: loading control. Data are expressed as fold change compared to the control group (n = 3).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Ang-(1–7)(Talfirastide, 10−6 mol/L, 24h) inhibits inflammation response by modulating the expression of inflammatory cytokines. Representative immunoblots and quantification showing protein expression of IL-1β and TNF-α in the macrophages after treatment for 24 h.

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Ang-(1–7) (Talfirastide; administered immediately by intrathecal injection; 10 μL; 500 ng) improved the motor function of rats after SCI. a Basso, Beattie and Bresnahan (BBB) scores (n = 6) and Inclined plane test scores (n = 6).

    Talfirastide acetate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23.  [Abstract]

    Continuous sections of the spinal cord by HE staining were obtained on the 28th day post-surgery, and the remaining neurons in the SCI group, SCI + Ang-(1–7) groups, and SCI + Ang-(1–7) + A779 groups at the same distance from the epicenter were displayed. (scale bar: 100 μm and 40 μm, n = 3).

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    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium[1][2][3].

    IC50 & Target

    AT1 Receptor

     

    In Vitro

    Angiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth[2].
    Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells[4].
    Angiotensin 1-7 signals through the Mas receptor ( MasR) in opposition to Ang II/angiotensin II type 1 receptor (AT1R), promoting anti-inflammatory,vasodilatory, and neuroprotective effects[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Talfirastide acetate Related Antibodies
    In Vivo

    Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    959.06

    Formula

    C43H66N12O13
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Asp-Arg-Val-Tyr-Ile-His-Pro
    Sequence Shortening

    DRVYIHP
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 62.5 mg/mL (65.17 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0427 mL 5.2134 mL 10.4269 mL
    5 mM 0.2085 mL 1.0427 mL 2.0854 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (104.27 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.0427 mL 5.2134 mL 10.4269 mL 26.0672 mL
    5 mM 0.2085 mL 1.0427 mL 2.0854 mL 5.2134 mL
    10 mM 0.1043 mL 0.5213 mL 1.0427 mL 2.6067 mL
    15 mM 0.0695 mL 0.3476 mL 0.6951 mL 1.7378 mL
    20 mM 0.0521 mL 0.2607 mL 0.5213 mL 1.3034 mL
    25 mM 0.0417 mL 0.2085 mL 0.4171 mL 1.0427 mL
    30 mM 0.0348 mL 0.1738 mL 0.3476 mL 0.8689 mL
    40 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
    50 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.5213 mL
    60 mM 0.0174 mL 0.0869 mL 0.1738 mL 0.4345 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Talfirastide acetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Talfirastide2855063-75-9TXA127Angiotensin (1-7)Ang-(1-7)TXA 127TXA-127Angiotensin ReceptorAngiotensin-converting Enzyme (ACE)Endogenous MetabolitemyofibroblasvasodilationRenin-AngiotensinSystemRAS cardiacatheroscleroticInhibitorinhibitorinhibit

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