1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Angiotensin Receptor
    Angiotensin-converting Enzyme (ACE)
    Endogenous Metabolite
  3. Angiotensin (1-7) (acetate)

Angiotensin (1-7) (acetate) (Synonyms: Ang-(1-7) (acetate))

Cat. No.: HY-12403A Purity: 98.91%
Handling Instructions

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.

For research use only. We do not sell to patients.

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Angiotensin (1-7) (acetate) Chemical Structure

Angiotensin (1-7) (acetate) Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in Water USD 101 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
25 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 252 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium[1][2][3].

IC50 & Target

IC50: 0.65 μM (ACE)[2]

In Vitro

Angiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth[2].
Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells[4].
Angiotensin 1-7 signals through the Mas receptor ( MasR) in opposition to Ang II/angiotensin II type 1 receptor (AT1R), promoting anti-inflammatory,vasodilatory, and neuroprotective effects[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

959.06

Formula

C₄₃H₆₆N₁₂O₁₃

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro

Sequence Shortening

DRVYIHP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (130.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0427 mL 5.2134 mL 10.4269 mL
5 mM 0.2085 mL 1.0427 mL 2.0854 mL
10 mM 0.1043 mL 0.5213 mL 1.0427 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

Angiotensin (1-7) (acetate)Ang-(1-7) (acetate)Angiotensin ReceptorAngiotensin-converting Enzyme (ACE)Endogenous MetabolitemyofibroblasvasodilationRenin-AngiotensinSystemRAS cardiacatheroscleroticInhibitorinhibitorinhibit

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Product Name:
Angiotensin (1-7) (acetate)
Cat. No.:
HY-12403A
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