1. GPCR/G Protein
  2. Angiotensin Receptor

C-Type Natriuretic Peptide (CNP) (1-22), human 

Cat. No.: HY-P1237
Handling Instructions

C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. C-type natriuretic peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone. Sequence: Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide bridge: Cys6-Cys22);GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

C-Type Natriuretic Peptide (CNP) (1-22), human Chemical Structure

C-Type Natriuretic Peptide (CNP) (1-22), human Chemical Structure

CAS No. : 127869-51-6

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5 mg USD 600 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. C-type natriuretic peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone. Sequence: Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide bridge: Cys6-Cys22);GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22).

In Vitro

C-Type Natriuretic Peptide (CNP) has been shown to be present in the central nervous system of mammals and to participate in the regulation of the homeostasis of the fluid, electrolytic balance and blood pressure, learning and memory[1].

In Vivo

I.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4550 mL 2.2752 mL 4.5504 mL
5 mM 0.0910 mL 0.4550 mL 0.9101 mL
10 mM 0.0455 mL 0.2275 mL 0.4550 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]

Rats are preliminarily kindled with picrotoxin and convulsion is monitored. Rats then receive I.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) (0.2, 1 or 2 nM in 2 mcl of 0.9% NaCI) under conditions of free behavior. Control animals receive an equal volume of saline. Within 10 min after the injections of the peptides, picrotoxin (1.5 mg/kg) is administered i.p. and the convulsion severity is evaluated as mentioned above[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2197.60

Formula

C₉₃H₁₅₇N₂₇O₂₈S₃

CAS No.

127869-51-6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
C-Type Natriuretic Peptide (CNP) (1-22), human
Cat. No.:
HY-P1237
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C-Type Natriuretic Peptide (CNP) (1-22), human

Cat. No.: HY-P1237