C-Type Natriuretic Peptide (CNP) (1-22), human TFA
Based on 2 publication(s) in Google Scholar
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 1966153-17-2
- Formula: C95H158F3N27O30S3
- Molecular Weight:2311.62
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) C-Type Natriuretic Peptide (CNP) (1-22), human TFA
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Customer Validation & Images
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Histological Imaging/Staining
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Histological Imaging/Staining
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In Vivo Efficacy Study
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IF
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RT-PCR
All Histamine Receptor Isoforms
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Biological Activity
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NPR-B |
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Dose (nM/kg) |
AUC0-∞ (pM·min/mL) |
MRT0-∞ (min) |
T1/2 (min) |
CLtot (mL/min/kg) |
Vdss (mL/kg) |
| 20 | 320±54 | 1.02±0.18 | 1.42±0.45 | 63.9±11.9 | 64.2±5.1 |
| Dose (nM/kg) |
Cmax (pM/mL) |
Tmax (min) |
AUC0-∞ (pM·min/mL) |
MRT0-∞ (min) |
T1/2 (min) |
BA (%) |
| 50 | 9.02±3.74 | 5.0±0.0 | 152±73 | 13.9±3.4 | 10.0±5.0 | 19±9 |
C-Type Natriuretic Peptide (CNP) (1-22) ( i.c.v.) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1966153-17-2
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Appearance Solid
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Molecular Weight 2311.62
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Formula C95H158F3N27O30S3
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Color White to off-white
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Sequence Shortening
GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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C-Type Natriuretic Peptide (CNP) (1-22), human TFA purchased from MedChemExpress. Usage Cited in: Compos B Eng. 2025 May 15.
The heart of each group was mapped with the location of the ligation line and the infarct area. Hydrogel+CNP (C-Type Natriuretic Peptide)/Sema3A group: CNP/Sema3A-loaded hydrogel was applied, in which CNP was loaded at a concentration of 50 μg/mL, and specimens were harvested at 7, 14 and 28 days after intervention.
C-Type Natriuretic Peptide (CNP) (1-22), human TFA purchased from MedChemExpress. Usage Cited in: Compos B Eng. 2025 May 15.
Enlarged image of Masson stain in local detail. Masson's trichrome staining further demonstrated apparent fibrosis formation and collagen deposition, accompanied by ventricular wall thinning in infarcted hearts. Hydrogel+CNP (C-Type Natriuretic Peptide)/Sema3A group: CNP/Sema3A-loaded hydrogel was applied, in which CNP was loaded at a concentration of 50 μg/mL, and specimens were harvested at 7, 14 and 28 days after intervention.
C-Type Natriuretic Peptide (CNP) (1-22), human TFA purchased from MedChemExpress. Usage Cited in: Compos B Eng. 2025 May 15.
Cardiac function was recorded by M-mode echocardiography, ejection fraction calculation and fractional shortening calculation, LVEDV, LVESV calculation.Hydrogel+CNP (C-Type Natriuretic Peptide)/Sema3A group: CNP/Sema3A-loaded hydrogel was applied, in which CNP was loaded at a concentration of 50 μg/mL, and specimens were harvested at 7, 14 and 28 days after intervention.
C-Type Natriuretic Peptide (CNP) (1-22), human TFA purchased from MedChemExpress. Usage Cited in: Compos B Eng. 2025 May 15.
α-SMA (green) and CD31 (red) representative immunofluorescence double staining. Hydrogel+CNP (C-Type Natriuretic Peptide)/Sema3A group: CNP/Sema3A-loaded hydrogel was applied, in which CNP was loaded at a concentration of 50 μg/mL, and specimens were harvested at 7, 14 and 28 days after intervention.
C-Type Natriuretic Peptide (CNP) (1-22), human TFA purchased from MedChemExpress. Usage Cited in: Compos B Eng. 2025 May 15.
The expressions of CD68, CD4, CD11c and CD19 in Hydrogel group and CNP/Sema3A-loaded hydrogel group were recorded. Hydrogel+CNP (C-Type Natriuretic Peptide)/Sema3A group: CNP/Sema3A-loaded hydrogel was applied, in which CNP was loaded at a concentration of 50 μg/mL, and specimens were harvested at 7, 14 and 28 days after intervention.
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Acta Biomater
The loading of C-type natriuretic peptides improved hemocompatibility and vascular regeneration of electrospun poly(ε-caprolactone) grafts. [Abstract]2022 Oct 1:151:304-316. PMID: 36002127
Solvent & Solubility
DMSO : 25 mg/mL (10.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (0.87 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Morozumi N, et al. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. PLoS One. 2019 Feb 22;14(2):e0212680. [Content Brief]
[2]. Buckley MG, et al. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72. [Content Brief]
[3]. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4326 mL | 2.1630 mL | 4.3260 mL | 10.8149 mL |
| 5 mM | 0.0865 mL | 0.4326 mL | 0.8652 mL | 2.1630 mL | |
| 10 mM | 0.0433 mL | 0.2163 mL | 0.4326 mL | 1.0815 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Classifications
HY-P1237A Related Classifications
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