Bilirubin
Based on 8 publication(s) in Google Scholar
Bilirubin is a yellow breakdown product of heme catabolism. Bilirubin exhibits antioxidant and antimutagenic effects.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Assay : 100.19%
- CAS No.: 635-65-4
- 화학식: C33H36N4O6
- 분자량:584.66
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-135005A
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HY-B0166
L-Ascorbic acidAntioxidant -
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PEG300Neutral Polymer -
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Taurocholic acidImmunoregulation Agent -
HY-13418A
DorsomorphinAMPK Inhibitor -
HY-D0844
Glutathione oxidizedAntioxidant -
HY-Y0320C
Dimethyl sulfoxideAprotic Solvent -
HY-D0842
BSA ProteinGlobular Protein -
HY-19424
HeminHeme Oxygenase-1 Inducer
Publications Citing Use of MedChemExpress (MCE) Bilirubin
More- Nat Immunol. 2026 May;27(5):949-960. [Abstract]
- Hepatology. 2024 Aug 1;80(2):403-417. [Abstract]
- Int J Nanomedicine. 2026 Jul 22:21:617608.
- J Virol. 2026 Feb 17;100(2):e0165625. [Abstract]
- PLoS Negl Trop Dis. 2025 Dec 11;19(12):e0013815. [Abstract]
- J Bone Oncol. 2023 Feb 23:39:100472. [Abstract]
- Adv Med Educ Pract. 2021 Mar 4:12:237-243. [Abstract]
- Curr Eye Res. 2023 Jan;48(1):25-33. [Abstract]
Customer Validation & Images
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RT-PCR
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Bio/Physico-chemical Assay
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
제품 설명
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Unconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 635-65-4
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Appearance Solid
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분자량 584.66
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화학식 C33H36N4O6
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Color Yellow to orange
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SMILES
CC(C(N/1)=O)=C(C=C)C1=C\C2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(/C=C4NC(C(C=C)=C\4C)=O)N3)N2
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (8)
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Journal Impact Factor
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Most Recent
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Nat Immunol
Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [Abstract]2026 May;27(5):949-960. PMID: 41781710 -
Hepatology
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. [Abstract]2024 Aug 1;80(2):403-417. PMID: 38377466
Bilirubin purchased from MedChemExpress. Usage Cited in: Hepatology. 2024 Aug 1;80(2):403-417. [Abstract]
Verification of the function of bilirubin as an AhR ligand using HepG2-Lucia AhR reporter cells.
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J Virol
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]2026 Feb 17;100(2):e0165625. PMID: 41489372 -
PLoS Negl Trop Dis
The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation. [Abstract]2025 Dec 11;19(12):e0013815. PMID: 41379884
Bilirubin purchased from MedChemExpress. Usage Cited in: PLoS Negl Trop Dis. 2025 Dec 11;19(12):e0013815. [Abstract]
HFF cells were incubated with vehicle and bilirubin (10 μM or 40 μM) 2 h before infection with Tg RH (MOI = 0.2). The relative intracellular parasite numbers were quantified by qPCR at 72 h post-infection.
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J Bone Oncol
Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS. [Abstract]2023 Feb 23:39:100472. PMID: 36876225
Bilirubin purchased from MedChemExpress. Usage Cited in: J Bone Oncol. 2023 Feb 23:39:100472. [Abstract]
Bilirubin (IBIL; 15 μM) markedly decreases the expression of MMP-2 and upregulates the expression of TIMP-2 in 143B and MG63 cells.
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Adv Med Educ Pract
Online Medical Education in India - Different Challenges and Probable Solutions in the Age of COVID-19. [Abstract]2021 Mar 4:12:237-243. PMID: 33692645 -
Curr Eye Res
HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production. [Abstract]2023 Jan;48(1):25-33. PMID: 36300537
용액&용해도
In Vitro:
0.1 M NaOH : 2 mg/mL (3.42 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)
0.1 M HCl : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (17.10 mM); Suspended solution; Need ultrasonic
순도&문서
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Data Sheet (295 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72. [Content Brief]
[2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH | 1 mM | 1.7104 mL | 8.5520 mL | 17.1040 mL | 42.7599 mL |
Bilirubin Related Classifications
HY-N0323 Related Classifications
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