2. GPCR/G Protein
    Metabolic Enzyme/Protease
  3. Angiotensin Receptor
    Angiotensin-converting Enzyme (ACE)
  4. Alamandine

Alamandine 

Cat. No.: HY-P3108 Purity: 98.95%
COA Handling Instructions

Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Alamandine Chemical Structure

Alamandine Chemical Structure

CAS No. : 1176306-10-7

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Based on 1 publication(s) in Google Scholar

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Description

Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].

In Vitro

Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood[1].
Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling[2].
Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Alamandine (0.15  μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (SHRs, 50-week-old)[3]
Dosage: 0.15  μL/h (~50 μg/kg/day)
Administration: Administered by mini-osmotic pumps; for 6 weeks
Result: Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function.
Molecular Weight

855.00

Appearance

Solid

Formula

C40H62N12O9
CAS No.
Sequence

Ala-Arg-Val-Tyr-Ile-His-Pro
Sequence Shortening

ARVYIHP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (29.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1696 mL 5.8480 mL 11.6959 mL
5 mM 0.2339 mL 1.1696 mL 2.3392 mL
10 mM 0.1170 mL 0.5848 mL 1.1696 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (29.24 mM); Clear solution; Need ultrasonic and warming

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Alamandine1176306-10-7Angiotensin ReceptorAngiotensin-converting Enzyme (ACE)Anti-hypertensiverenin-angiotensinMrgDvasoactivepeptidecardioprotectiveanti-fibroticInhibitorinhibitorinhibit

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