1. GPCR/G Protein
  2. Angiotensin Receptor

BIBS 39 (Synonyms: BIBS39; BIBS-39)

Cat. No.: HY-19732 Purity: 99.36%
Data Sheet SDS Handling Instructions

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.

For research use only. We do not sell to patients.
BIBS 39 Chemical Structure

BIBS 39 Chemical Structure

CAS No. : 133085-33-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $242 In-stock
5 mg $210 In-stock
10 mg $360 In-stock
25 mg $700 In-stock
50 mg $910 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptor in vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 ± 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 ± 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 ± 7 nM for the AT1 subtype and a Ki value of 730 ± 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times. BIBS 39 shifts the AII concentration-contractile response curves in isolated rabbit aorta to the right in a parallel fashion. [1] in vivo: In pithed rats, BIBS 39 dependently shifts the dose-response curve of AII to the right without affecting the maximal response. BIBS 222 also causes parallel shifts to the right but a significant reduction of the maximal responses was observed at 3 and 10 mg/kg i.v. These results show that the benzimidazole derivatives BIBS 39 is a potent and selective AII receptor antagonists. Substitution with a benzimidazole moiety results into a considerable loss of selectivity for the AT1 receptor subtype compared with an imidazole moiety as, for instance, in DuP 753.[1] BIBS 39 is a new nonpeptide angiotensin receptor blockers that has affinity for both AT1- and AT2-receptors, is also a potent antagonist of the cardiovascular effects of AII in pithed rabbits. [2]

References
M.Wt

524.65

Formula

C₃₂H₃₆N₄O₃

CAS No.

133085-33-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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BIBS 39
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