1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Hypophyllanthin

Hypophyllanthin 

Cat. No.: HY-N4108
Handling Instructions

Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity.

For research use only. We do not sell to patients.

Hypophyllanthin Chemical Structure

Hypophyllanthin Chemical Structure

CAS No. : 33676-00-5

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Description

Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].

IC50 & Target

P-gp[2]

In Vitro

Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1].

Molecular Weight

430.49

Formula

C₂₄H₃₀O₇

CAS No.

33676-00-5

SMILES

COC[[email protected]@H]1[[email protected]@H](COC)CC2=CC(OC)=C(OCO3)C3=C2[[email protected]]1C4=CC=C(OC)C(OC)=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HypophyllanthinP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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Hypophyllanthin
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