1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Alclometasone

Alclometasone (Synonyms: 7a-​Chloro-​16a-​methyl prednisolone)

Cat. No.: HY-A0150
Handling Instructions

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis.

For research use only. We do not sell to patients.

Alclometasone Chemical Structure

Alclometasone Chemical Structure

CAS No. : 67452-97-5

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Description

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1].

IC50 & Target

IC50: glucocorticoid receptor[1]

In Vivo

The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2].

Molecular Weight

408.92

Formula

C₂₂H₂₉ClO₅

CAS No.

67452-97-5

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Alclometasone7a-​Chloro-​16a-​methyl prednisoloneGlucocorticoid ReceptorContactdermatitispsoriasis,eczemacorticosteroideczemaInhibitorinhibitorinhibit

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