1. Immunology/Inflammation
  2. Glucocorticoid Receptor
  3. Alclometasone

Alclometasone  (Synonyms: 7a-​Chloro-​16a-​methyl prednisolone)

Cat. No.: HY-A0150
Handling Instructions

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis.

For research use only. We do not sell to patients.

Alclometasone Chemical Structure

Alclometasone Chemical Structure

CAS No. : 67452-97-5

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Description

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1].

IC50 & Target

IC50: glucocorticoid receptor[1]

In Vivo

The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

408.92

Formula

C22H29ClO5

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Alclometasone
Cat. No.:
HY-A0150
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