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Bermoprofen (Synonyms: AD-1590)

Cat. No.: HY-118561
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Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic and analgesic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits.

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Bermoprofen Chemical Structure

Bermoprofen Chemical Structure

CAS No. : 78499-27-1

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Description

Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic and analgesic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits[1][2].

In Vitro

Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents[1].

In Vivo

Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits[2].

Animal Model: Male albino rabbits, 2.3-3 kg[2]
Dosage: 0.04, 0.4, 0.1 mg/kg
Administration: Oral; given 1 h after i.v. injection of LPS
Result: Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg.
Molecular Weight

296.32

Formula

C₁₈H₁₆O₄

CAS No.

78499-27-1

SMILES

O=C(O)C(C)C1=CC=C(C2=C1)OC3=CC=C(C)C=C3CC2=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BermoprofenAD-1590AD1590AD 1590Othersnonsteroidalanti-inflammatorantipyreticanalgesicfeverInhibitorinhibitorinhibit

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Bermoprofen
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