2. Membrane Transporter/Ion Channel Cytoskeleton Metabolic Enzyme/Protease
  3. Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
  4. Meclofenamic acid sodium hydrate

Meclofenamic acid sodium hydrate  (Synonyms: Meclofenamate sodium hydrate)

Cat. No.: HY-117275A
Handling Instructions

Molarity Calculator

Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively.

For research use only. We do not sell to patients.

Meclofenamic acid sodium hydrate Chemical Structure

Meclofenamic acid sodium hydrate Chemical Structure

CAS No. : 67254-91-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Meclofenamic acid sodium hydrate:

Other Forms of Meclofenamic acid sodium hydrate:

Meclofenamic acid sodium hydrate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Meclofenamic acid sodium hydrate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].

IC50 & Target

IC50: 1 μM (cyclooxygenase), 56.0 μM (hKv2.1), 155.9 μM (hKv1.1)[3]
In Vitro

Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner[1].
Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins[2].
Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meclofenamic acid sodium hydrate Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 12.5, 25, 50, 100 μM
Incubation Time: 24 h
Result: Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.
Clinical Trial
Molecular Weight

336.15

Formula

C14H12Cl2NNaO3
CAS No.
SMILES

O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl.O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Meclofenamic acid sodium hydrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meclofenamic acid sodium67254-91-5Meclofenamate sodiumFat Mass and Obesity-associated Protein (FTO)Potassium ChannelGap Junction ProteinEndogenous MetaboliteKcsAneuronalpotassium channelK+ channelvoltage-gatedhKv2.1anti-inflammatoryRGCsgap junctionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Meclofenamic acid sodium hydrate
Cat. No.:
HY-117275A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.