2. Immunology/Inflammation
  3. NO Synthase
  4. (Rac)-ZLc-002

(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability.

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(Rac)-ZLc-002 Chemical Structure

(Rac)-ZLc-002 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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(Rac)-ZLc-002 Related Antibodies

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Description

(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability[1][2].

IC50 & Target

nNOS/NOS1AP interaction[1]
In Vitro

(Rac)-ZLc-002 (10 μM) reduces co-immunoprecipitation of NOS1AP with nNOS immunoprecipitated from primary cultured cortical neurons. (Rac)-ZLc-002 fails to disrupt nNOS–NOS1AP protein–protein interactions in the AlphaScreen in vitro binding assay. It shows no activity in a cell-free assay[1].
(Rac)-ZLc-002 (10 μM) reduces co-immunoprecipitation of full-length NOS1AP but not of PSD95-PDZ2 from HEK293T cells co-expressing full-length nNOS[1].
(Rac)-ZLc-002 (0-50 μM; 72 h) synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-ZLc-002 Related Antibodies

Cell Viability Assay[1]

Cell Line: 4T1 cells
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Treatment alone had no effect on the viability. Showed synergistic effect with Paclitaxel (HY-B0015).
In Vivo

(Rac)-ZLc-002 (10 mg/kg; i.p.; once or daily for 8 days) attenuates mechanical and cold allodynia evoked by Paclitaxel (HY-B0015), suppresses Paclitaxel-induced neuropathic pain in a mouse model[1].
(Rac)-ZLc-002 (4 and 10 mg/kg; i.p.; once) reduces formalin-evoked nociceptive behavior and Fos-like immunoreactivity in the spinal dorsal horn in rats[1].
(Rac)-ZLc-002 (40 mg/kg/day; i.v.; 7 days) attenuates chronic mild stress (CMS)‐induced anxiogenic behavior in ICR mice[2].
(Rac)-ZLc-002 (10 μM; 1 μl; 30 min after Corticosterone, HY-B1618) delivering into the hippocampus for 7 days reverses the behavioural effects of glucocorticoids in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult C57BL/6J male mice, paclitaxel model of neuropathic pain[1]
Dosage: 10 mg/kg
Administration: IP, once or daily for 8 days
Result: Increased postinjection mechanical paw withdrawal thresholds, mechanical paw withdrawal thresholds differed across postinjection times, and the interaction between drug treatment and injection time was significant. Elevated mechanical paw withdrawal thresholds relative to vehicle treatment from 30 min. Decreased postinjection cold responsiveness, cold responsiveness did not differ reliably across postinjection times, and the interaction between drug treatment and injection time was not significant. Once daily dosing increased mechanical paw withdrawal thresholds relative to the vehicle-treated group across the observation interval.
Molecular Weight

231.25

Formula

C10H17NO5
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC)CC(NC(C(OC)=O)C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (432.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3243 mL 21.6216 mL 43.2432 mL
5 mM 0.8649 mL 4.3243 mL 8.6486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3243 mL 21.6216 mL 43.2432 mL 108.1081 mL
5 mM 0.8649 mL 4.3243 mL 8.6486 mL 21.6216 mL
10 mM 0.4324 mL 2.1622 mL 4.3243 mL 10.8108 mL
15 mM 0.2883 mL 1.4414 mL 2.8829 mL 7.2072 mL
20 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4054 mL
25 mM 0.1730 mL 0.8649 mL 1.7297 mL 4.3243 mL
30 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6036 mL
40 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7027 mL
50 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
60 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
80 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3514 mL
100 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
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(Rac)-ZLc-002 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-ZLc-002NO SynthaseNitric oxide synthasesNOSanxiolytic-likeNOS1APnNOSInhibitorinhibitorinhibit

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