1. Terpenoids and Glycosides
  2. Euphol

Euphol 

Cat. No.: HY-N0313
Handling Instructions

Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain.

For research use only. We do not sell to patients.

Euphol Chemical Structure

Euphol Chemical Structure

CAS No. : 514-47-6

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Description

Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1].

IC50 & Target

IC50: 315 nM (monoacylglycerol lipase activity)[1]

In Vitro

Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively[2].
Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins[2].

Cell Proliferation Assay[2]

Cell Line: T47D cells
Concentration: 0.01, 0.03, 0.1 and 0.3 mM
Incubation Time: 24, 48 and 72 hours
Result: Decreased the percentage of viable cells.

Western Blot Analysis[2]

Cell Line: T47D cells
Concentration: 0.03 mM
Incubation Time: 48 and 72 hours
Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D.
Molecular Weight

426.72

Formula

C₃₀H₅₀O

CAS No.

514-47-6

SMILES

C[[email protected]@]1(CC2)[[email protected]@](CC[[email protected]]1([[email protected]](C)CC/C=C(C)/C)[H])(C)C3=C2[[email protected]]4(C)[[email protected]](CC3)([H])C(C)(C)[[email protected]@H](O)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Euphol
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HY-N0313
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