Heme Oxygenase-2-IN-1

Cat. No.: HY-147817 Pureza: 98.82%: Ficha de datos
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Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC₅₀ values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively.

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Heme Oxygenase-2-IN-1 Estructura química

No. CAS : 2994198-37-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

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Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC₅₀ values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively^[1].

IC₅₀ & Target

IC₅₀: 0.9 μM (HO-2), 14.9 μM (HO-1)^[1]

Peso molecular

319.36

Fòrmula

C₁₉H₁₇N₃O₂

No. CAS

2994198-37-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=C(COC2=CC=C(C(O)CN3C=CN=C3)C=C2)C=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 83.33 mg/mL (260.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1313 mL	15.6563 mL	31.3126 mL
5 mM	0.6263 mL	3.1313 mL	6.2625 mL
10 mM	0.3131 mL	1.5656 mL	3.1313 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.82%

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Ficha de datos (269 KB) SDS (254 KB)

COA (246 KB) HNMR (280 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Floresta G, et al. Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region. Bioorg Chem. 2020 Nov;104:104310. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1313 mL	15.6563 mL	31.3126 mL	78.2816 mL
	5 mM	0.6263 mL	3.1313 mL	6.2625 mL	15.6563 mL
	10 mM	0.3131 mL	1.5656 mL	3.1313 mL	7.8282 mL
	15 mM	0.2088 mL	1.0438 mL	2.0875 mL	5.2188 mL
	20 mM	0.1566 mL	0.7828 mL	1.5656 mL	3.9141 mL
	25 mM	0.1253 mL	0.6263 mL	1.2525 mL	3.1313 mL
	30 mM	0.1044 mL	0.5219 mL	1.0438 mL	2.6094 mL
	40 mM	0.0783 mL	0.3914 mL	0.7828 mL	1.9570 mL
	50 mM	0.0626 mL	0.3131 mL	0.6263 mL	1.5656 mL
	60 mM	0.0522 mL	0.2609 mL	0.5219 mL	1.3047 mL
	80 mM	0.0391 mL	0.1957 mL	0.3914 mL	0.9785 mL
	100 mM	0.0313 mL	0.1566 mL	0.3131 mL	0.7828 mL