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Hydrocortisone buteprate (Synonyms: Hydrocortisone probutate; HBP)

Cat. No.: HY-106673 Purity: 99.80%
Handling Instructions

Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation.

For research use only. We do not sell to patients.

Hydrocortisone buteprate Chemical Structure

Hydrocortisone buteprate Chemical Structure

CAS No. : 72590-77-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 260 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation[1].

Molecular Weight

488.61

Formula

C₂₈H₄₀O₇

CAS No.

72590-77-3

SMILES

CCC(OCC([[email protected]@]1([[email protected]@]2([[email protected]@]([[email protected]@]3([H])[[email protected]]([[email protected]@]4(C(CC3)=CC(CC4)=O)C)([H])[[email protected]@H](O)C2)([H])CC1)C)OC(CCC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (511.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0466 mL 10.2331 mL 20.4662 mL
5 mM 0.4093 mL 2.0466 mL 4.0932 mL
10 mM 0.2047 mL 1.0233 mL 2.0466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Hydrocortisone buteprate
Cat. No.:
HY-106673
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