1. Immunology/Inflammation
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  3. SC-58125

SC-58125 

Cat. No.: HY-W013164
Handling Instructions

SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic.

For research use only. We do not sell to patients.

SC-58125 Chemical Structure

SC-58125 Chemical Structure

CAS No. : 162054-19-5

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Description

SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic[1][2][3].

IC50 & Target[1]

hCOX-2

0.04 μM (IC50)

hCOX-1

>100 μM (IC50)

In Vitro

SC-58125 (0.001-100 μM) has a high degree of selectivity for the inducible form of COX-2 (IC50=1 μM) over the COX-1 (IC50>100 μM)[1].
SC-58125 (10 μM; 20-140 s) is time-dependent and is complete by 1 min, with a half-maximal inhibition at 20 s[1].
SC-58125 (25-100 μM; 3 d) inhibits the in vitro growth of HCA-7 and LLC cells[3].
SC-58125 (100 µM; 12 h) induces G2 arrest in LLC cells[3].
SC-58125 (25-100 μM; 3 d) decreases p34cdc2 levels in HCA-7 cells[3].
SC-58125 (100 µM; 24 or 72 h) does not induce apoptosis of HCA-7 and LLC cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HCA-7 and LLC cells
Concentration: 0, 25, 50, 100 μM
Incubation Time: 3 days
Result: Reduced the cell number and MTT activity in both cell lines in a dose-dependent manner.

Cell Cycle Analysis[3]

Cell Line: LLC cells
Concentration: 100 μM
Incubation Time: 12 hours
Result: Increased in the number of cells containing 4n DNA content in a dose- and time-dependent manner.
Reduced the number of mitotic figures.

Western Blot Analysis[3]

Cell Line: HCA-7 cells
Concentration: 0, 25, 50, 100 μM
Incubation Time: 3 days
Result: Resulted in a dose-dependent decrease in p34cdc2 activity with strong inhibition, even at the lowest concentration.
In Vivo

SC-58125 (10 mg/kg; i.p. every 48 h) inhibits the growth of established colorectal cancer xenografts in mice[3].
SC-58125 (10 mg/kg; a single i.p.) reduces tumor PGE2 levels in mice[3].
SC-58125 (10 mg/kg; a single i.p.) does not change the tumor levels of COX-1 and COX-2 protein in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic Sprague-Dawley mice are injected HCA-7 cells[3]
Dosage: 10 mg/kg
Administration: I.p. every 48 h; at the time of tumor implantation or 2 and 4 weeks later
Result: Decreased the tumor growth rates significantly.
Molecular Weight

384.35

Formula

C₁₇H₁₂F₄N₂O₂S

CAS No.

162054-19-5

SMILES

FC(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(F)C=C3)=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SC-58125SC58125SC 58125COXCyclooxygenasecyclooxygenase2COX-2antitumoredemainflammatorycancerInhibitorinhibitorinhibit

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