2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Kumujian A

Kumujian A  (Synonyms: 1-Ethoxycarbonyl-β-carboline)

Cat. No.: HY-N10450 Purity: 98.32%
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Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL).

For research use only. We do not sell to patients.

Kumujian A Chemical Structure

Kumujian A Chemical Structure

CAS No. : 72755-19-2

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1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL)[1].

Molecular Weight

240.26

Formula

C14H12N2O2
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)OCC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (416.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1622 mL 20.8108 mL 41.6216 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1622 mL 20.8108 mL 41.6216 mL 104.0539 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL 20.8108 mL
10 mM 0.4162 mL 2.0811 mL 4.1622 mL 10.4054 mL
15 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9369 mL
20 mM 0.2081 mL 1.0405 mL 2.0811 mL 5.2027 mL
25 mM 0.1665 mL 0.8324 mL 1.6649 mL 4.1622 mL
30 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
40 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
50 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0811 mL
60 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
80 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
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Kumujian A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kumujian A72755-19-21-Ethoxycarbonyl-β-carbolineReactive Oxygen Speciessuperoxide anion generationanti-inflammatoryelastase releaseInhibitorinhibitorinhibit

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