1. Saccharides and Glycosides
    Flavonoids
  2. Hydroxysafflor yellow A

Hydroxysafflor yellow A (Synonyms: Safflomin A; HSYA)

Cat. No.: HY-N0567 Purity: 95.13%
Handling Instructions

Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L.

For research use only. We do not sell to patients.

Hydroxysafflor yellow A Chemical Structure

Hydroxysafflor yellow A Chemical Structure

CAS No. : 78281-02-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 312 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possesses anti-tumor activity. IC50 value: Target: in vitro: HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. We further showed that HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway [1]. HSYA protected EC viability against LPS-induced injury (P<0.05). LPS-induced NF-κB p65 subunit DNA binding (P<0.01) and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor -α (I-κB-α) phosphorylation was inhibited by HSYA. HSYA attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK [2]. HSYA inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. HSYA (1 mg/l) notably reduced the amount of intracellular lipid and triglyceride content in adipocytes by 21.3 % (2.13 ± 0.36 vs 2.71 ± 0.40, P < 0.01) and 22.6 % (1.33 ± 0.07 vs 1.72 ± 0.07, P < 0.01) on days 8 following the differentiation, respectively [3]. in vivo: HSYA treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronan (HA), laminin (LN), and type III precollagen (III-C) in rats [4].

Molecular Weight

612.53

Formula

C₂₇H₃₂O₁₆

CAS No.

78281-02-4

SMILES

OC(C(O)=C1C(/C=C/C2=CC=C(O)C=C2)=O)([[email protected]]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)([H])O[[email protected]@H]3CO)C(O)=C([[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]4O)O)O[[email protected]@H]4CO)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (55.51 mM)

H2O : 33.33 mg/mL (54.41 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6326 mL 8.1629 mL 16.3257 mL
5 mM 0.3265 mL 1.6326 mL 3.2651 mL
10 mM 0.1633 mL 0.8163 mL 1.6326 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 95.13%

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Keywords:

Hydroxysafflor yellow ASafflomin A HSYAOthersInhibitorinhibitorinhibit

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Hydroxysafflor yellow A
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