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MDL 19301 

Cat. No.: HY-100286
Handling Instructions

MDL 19301 is a nonsteroidal, anti-inflammatory agent.

For research use only. We do not sell to patients.

MDL 19301 Chemical Structure

MDL 19301 Chemical Structure

CAS No. : 89388-38-5

Size Price Stock
1 mg USD 626 Get quote
5 mg USD 1001 Get quote
10 mg USD 1502 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


MDL 19301 is a nonsteroidal, anti-inflammatory agent.

In Vivo

Oral administration of MDL 19301 inhibits rat paw edema induced by carrageenan (ED30=4.8 mg/kg) or an Arthus reaction (ED30=8.2 mg/kg p.o.). The oral dose which induces gastric ulceration in 50% of fasted rats is greater than 1,000 mg/kg, demonstrating a more favorable therapeutic ratio than conventional nonsteroidal anti‐inflammatory agents. The anti-inflammatory activity of MDL 19301, but not that of MDL 16,861, is attenuated by co-administration of an inhibitor of drug metabolite (SKF525A). This suggests that MDL 19301 is a prodrug of MDL 16,861 and this phenomenon would explain its lack of ulcerogenicity. Additional anti-inflammatory properties of MDL 19301 include inhibition of carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Other pharmacological data indicate that MDL 19301 administration results in inhibition of prostaglandin synthesis; inhibition of arachidonic acid-induced, but not prostaglandin-E2-induced, diarrhea in mice; and inhibition of ex vivo arachidonic-acid-induced, but not ADP-induced, rat platelet aggregation. MDL 19301 and MDL 16,861 are unexpectedly weak antipyretic agents in rats[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5783 mL 17.8916 mL 35.7833 mL
5 mM 0.7157 mL 3.5783 mL 7.1567 mL
10 mM 0.3578 mL 1.7892 mL 3.5783 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
MDL 19301
Cat. No.:

MDL 19301

Cat. No.: HY-100286