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Art. -Nr.: HY-151403

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Antimicrobial agent-9

Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity.

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CAS. Nr.: 2978694-25-4
Formel: C₄₃H₆₂N₁₆
Molecular Weight:803.06

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antimicrobial agent-9 Chemical Structure

CAS. Nr.: 2978694-25-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antimicrobial agent-9 (Compound 16) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 4.5 μg/mL^[1].
Antimicrobial agent-9 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 113.8^[1].
Antimicrobial agent-9 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells^[1].
Antimicrobial agent-9 is resistant to various physiological salts, human serum, and proteases^[1].
Antimicrobial agent-9 exhibits synergistic antimicrobial activity in combination with three conventional antibiotics (Chloramphenicol (HY-B0239), Ciprofloxacin (HY-B0356), and oxacillin) against MDRPA and MRSA, is promising adjuvants in combination with clinically used antibiotics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration:

0-256 μg/mL
Incubation Time:

18-24 h
Result:

Inhibited bacterial growth with MICs of 4, 8, 4 and 2 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.

Cell Viability Assay^[1]

Cell Line:

LPS-stimulated RAW 264.7 macrophages
Concentration:

5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
Incubation Time:

18 h
Result:

Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.

Chemical Information

CAS. Nr. 2978694-25-4
Molecular Weight 803.06
Formel C₄₃H₆₂N₁₆
SMILES

NCCCN(C1=NC(NCC2=CC=CC=C2)=NC(N3CCN(C4=NC(NCC5=CC=CC=C5)=NC(N(CCCN)CCCN)=N4)C(CC6=CC=CC=C6)C3)=N1)CCCN
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dinesh Kumar S, et al. Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents. Eur J Med Chem. 2022 Sep 8;243:114747. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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