2. Anti-infection
  3. Bacterial
  4. Antimicrobial agent-9

Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity.

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Antimicrobial agent-9 Chemical Structure

Antimicrobial agent-9 Chemical Structure

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Antimicrobial agent-9 Related Antibodies

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Description

Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity[1].

In Vitro

Antimicrobial agent-9 (Compound 16) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 4.5 μg/mL[1].
Antimicrobial agent-9 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 113.8[1].
Antimicrobial agent-9 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells[1].
Antimicrobial agent-9 is resistant to various physiological salts, human serum, and proteases[1].
Antimicrobial agent-9 exhibits synergistic antimicrobial activity in combination with three conventional antibiotics (Chloramphenicol (HY-B0239), Ciprofloxacin (HY-B0356), and oxacillin) against MDRPA and MRSA, is promising adjuvants in combination with clinically used antibiotics[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimicrobial agent-9 Related Antibodies

Cell Viability Assay[1]

Cell Line: E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration: 0-256 μg/mL
Incubation Time: 18-24 h
Result: Inhibited bacterial growth with MICs of 4, 8, 4 and 2 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.

Cell Viability Assay[1]

Cell Line: LPS-stimulated RAW 264.7 macrophages
Concentration: 5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
Incubation Time: 18 h
Result: Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.
Molecular Weight

803.06

Formula

C43H62N16
SMILES

NCCCN(C1=NC(NCC2=CC=CC=C2)=NC(N3CCN(C4=NC(NCC5=CC=CC=C5)=NC(N(CCCN)CCCN)=N4)C(CC6=CC=CC=C6)C3)=N1)CCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimicrobial agent-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimicrobial agent-9Antimicrobial agent9Antimicrobial agent 9Bacterialantimicrobialanti-inflammatoryE. coliP. aeruginosaS. epidermidisS. aureusInhibitorinhibitorinhibit

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