1. Immunology/Inflammation
    Apoptosis
  2. COX
    Apoptosis
  3. Diclofenac-13C6 sodium heminonahydrate

Diclofenac-13C6 sodium heminonahydrate 

Cat. No.: HY-15037S
Handling Instructions

Diclofenac-13C6 sodium heminonahydrate is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

For research use only. We do not sell to patients.

Diclofenac-13C6 sodium heminonahydrate Chemical Structure

Diclofenac-13C6 sodium heminonahydrate Chemical Structure

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Description

Diclofenac-13C6 sodium heminonahydrate is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

405.16

Formula

13C6C8H10Cl2NNaO2.4.5H2O

SMILES

O=C(O[Na])C[13C]([13CH]=[13CH][13CH]=[13CH]1)=[13C]1NC2=C(C=CC=C2Cl)Cl.[4.1/2].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Diclofenac-13C6 sodium heminonahydrate
Cat. No.:
HY-15037S
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