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Cat. No.: HY-A0259

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Floctafenine

Customer Review

Based on 1 Customer Validation

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research.

For research use only. We do not sell to patients.

Purity: 95.28%

CAS No.: 23779-99-9

Formula: C₂₀H₁₇F₃N₂O₄

Molecular Weight:406.36

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Data Sheet (276 KB)

SDS

COA

Floctafenine Chemical Structure

CAS No.: 23779-99-9

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Data Download

Data Sheet (276 KB)

SDS

COA

Handling Instructions (2659 KB)

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Biological Activity

Chemical Information

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References

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

All COX Isoforms
More

COX

COX-1

COX-2

COX-3

Biological Activity

Description

IC₅₀ & Target

In Vitro

In Vivo

Chemical Information

Solvent & Solubility

In Vitro

Purity & Documentation

References

Help & FAQs

Classifications

Bioz

Biological Activity

Description

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent^[1]^[2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research^[3].

IC₅₀ & Target^[1]

COX-1

COX-2

All COX Isoforms :

COX

COX-1

COX-2

COX-3

In Vitro

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC₅₀ values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples^[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 23779-99-9

Appearance Solid

Molecular Weight 406.36

Formula C₂₀H₁₇F₃N₂O₄

Color White to off-white

SMILES

O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=C(C(F)(F)F)C=CC=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (246.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4609 mL

12.3044 mL

24.6087 mL

5 mM

0.4922 mL

2.4609 mL

4.9217 mL

10 mM

0.2461 mL

1.2304 mL

2.4609 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)

SDS (393 KB)

English - EN (393 KB)

Français - FR (393 KB)

Deutsch - DE (393 KB)

Norwegian - NO (393 KB)

Español - ES (393 KB)

Swedish - SV (393 KB)

Italian - IT (393 KB)

Korean - KR (393 KB)

Portuguese - PT (393 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78(1):74-8. [Content Brief]

[2]. Gehan Hegazy Hegazy, et al. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity. Arch Pharm (Weinheim). 2005 Aug;338(8):378-84. [Content Brief]

[3]. R Maenthaisong, et al. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.Int J Immunopathol Pharmacol. Apr-Jun 2013;26(2):403-17. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.4609 mL 12.3044 mL 24.6087 mL 61.5218 mL

5 mM 0.4922 mL 2.4609 mL 4.9217 mL 12.3044 mL

10 mM 0.2461 mL 1.2304 mL 2.4609 mL 6.1522 mL

15 mM 0.1641 mL 0.8203 mL 1.6406 mL 4.1015 mL

20 mM 0.1230 mL 0.6152 mL 1.2304 mL 3.0761 mL

25 mM 0.0984 mL 0.4922 mL 0.9843 mL 2.4609 mL

30 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0507 mL

40 mM 0.0615 mL 0.3076 mL 0.6152 mL 1.5380 mL

50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2304 mL

60 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0254 mL

80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7690 mL

100 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL

Floctafenine Related Classifications

HY-A0259 Related Classifications

Immunology/Inflammation

COX

Disease Areas

Inflammation or Immune System Disease

Inflammation/Immunology

Powered by Bioz See more details on Bioz

Keywords

Floctafenine
23779-99-9
COX
nonsteroidal anti-inflammatory agent
NSAID
anti-inflammatory
acute inflammation
paw edema
postoperative pain
osteoarthritic
ulcerogenic
Inhibitor
inhibitor
inhibit

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Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4609 mL	12.3044 mL	24.6087 mL	61.5218 mL
5 mM	0.4922 mL	2.4609 mL	4.9217 mL	12.3044 mL
10 mM	0.2461 mL	1.2304 mL	2.4609 mL	6.1522 mL
15 mM	0.1641 mL	0.8203 mL	1.6406 mL	4.1015 mL
20 mM	0.1230 mL	0.6152 mL	1.2304 mL	3.0761 mL
25 mM	0.0984 mL	0.4922 mL	0.9843 mL	2.4609 mL
30 mM	0.0820 mL	0.4101 mL	0.8203 mL	2.0507 mL
40 mM	0.0615 mL	0.3076 mL	0.6152 mL	1.5380 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL	1.2304 mL
60 mM	0.0410 mL	0.2051 mL	0.4101 mL	1.0254 mL
80 mM	0.0308 mL	0.1538 mL	0.3076 mL	0.7690 mL
100 mM	0.0246 mL	0.1230 mL	0.2461 mL	0.6152 mL

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