1. Immunology/Inflammation
  2. COX
  3. Floctafenine

Floctafenine 

Cat. No.: HY-A0259
Handling Instructions

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain treatment.

For research use only. We do not sell to patients.

Floctafenine Chemical Structure

Floctafenine Chemical Structure

CAS No. : 23779-99-9

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Description

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent[1][2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain treatment[3].

IC50 & Target[1]

COX-1

 

COX-2

 

In Vitro

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC50 values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.36

Formula

C₂₀H₁₇F₃N₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Floctafenine
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HY-A0259
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