2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. ROS Kinase Interleukin Related
  4. Anti-inflammatory agent 64

Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of IL-6 and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema .

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Anti-inflammatory agent 64 Chemical Structure

Anti-inflammatory agent 64 Chemical Structure

CAS No. : 3016401-76-3

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Anti-inflammatory agent 64 Related Antibodies

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Description

Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of IL-6 and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema [1].

In Vitro

Anti-inflammatory agent 64 (2 μM, 4 h) can significantly protect cells and promote cell proliferation in RAW264.7 cells stimulated by H2O2 (0.4 mM[1].
Anti-inflammatory agent 64 (2 μM, 24 h) inhibits the production of NO (IC50=0.9 μM) in RAW264.7 cells stimulated by LPS (1 μg/mL) and has anti-inflammatory effect[1].
Anti-inflammatory agent 64 (0.125-2 μM, 4-24 h) significantly reduces the protein level of ROS and enhances HO-1 protein level in RAW264.7 cells stimulated by Rot (5 μM) and LPS (1 μM/mL) and has antioxidant effect[1].
Anti-inflammatory agent 64 (0.5-2 μM, 24 h) can restrain IL–6 in dose dependent manner (IC50=1.73 μM) and TNF-α (IC50=1.52 μM)[1].
Anti-inflammatory agent 64 (0.5-2 μM) can inhibit the expresstion of iNOS protein[1].
Anti-inflammatory agent 64 (0.5-2 μM) inhibits the avtivition of NF-κB pathway by inhibiting the degradation and phosphorylation of IκBα in RAW264.7 cells stimulated by LPS (1 μg/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 64 Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW264.7
Concentration: 2 μM
Incubation Time: 4 h
Result: Could effectively protect the cells treated with LPS, and the cell survival rate is 85%.
Could effectively inhibit inflammatory factors ON and had anti-inflammatory properties.
In Vivo

Anti-inflammatory agent 64 (1-30 mg/kg, i.p., i.g., single dose) has anti-inflammatory and antioxidant activity in carrageenan (Cg) (HY-125474) induced paw edema model [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cg-induced mouse paw edema model[1]
Dosage: 1 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection (i.p.) and intragastrica (i.g.), single dose
Result: Could significantly inhibit plantar edema
Reduced the expression level of iNOS.
Decreased the level of oxidation marker MAD and increased the activity of antioxidant enzyme SOD.
Increased HO-1 expression in a dose-dependent manner.
Molecular Weight

372.85

Formula

C20H21ClN2O3
CAS No.
SMILES

O=C(NCCCN1CCC2=C1C=CC(Cl)=C2)/C=C/C3=CC(O)=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Anti-inflammatory agent 64 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 643016401-76-3ROS KinaseInterleukin RelatedILPaw edemaInflammationIL-6TNF-αRAW264.7AntioxidantAnti-inflammatoryCg-induced paw edema modelInhibitorinhibitorinhibit

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