Fibrinogen (Bovine)
Based on 2 publication(s) in Google Scholar
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases.
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- CAS No.: 9001-32-5
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Publications Citing Use of MedChemExpress (MCE) Fibrinogen (Bovine)
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2D/3D Cell Culture and Differentiation
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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Histological Imaging/Staining
Activité biologique
Description
IC50 & Target
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IL-8 |
p50 |
p65 |
c-Rel |
In Vitro
Fibrinogen (0.3, 2, 4 mg/mL; 30 min) can induce a dose-dependent increase in the permeability of the endothelial cell layer to albumin, leading to the formation of gaps between endothelial cells and consequent albumin leakage[2].
Fibrinogen (2, 4 mg/mL; 1, 6, 12, 24 hours) increases leakage through the endothelial cell monolayer with time and dose[2].
Fibrinogen (4 mg/mL; 30 min) causes a dose-dependent increase in F-actin formation as well as gap formation in the endothelial cell monolayer[2].
Fibrinogen (2, 4 mg/mL; 30 min) can trigger a dose-dependent increase in ERK phosphorylation[2].
Fibrinogen (1000 µg/ml, 4 hours) can regulate the activation of NF-κB in endothelial cells (HUVEC) and specifically bind with the subunits p50, p65, c-Rel[3].
Fibrinogen (250 µg/mL, 4 hours) induces the activation of NF-κB, which is independent of Polybacterial B (HY-K1044) (5 µg/ml) and IL-1β (HY-P80503) (5 µg/ml)[3]
Fibrinogen (100, 250, 500, 1000 µg/mL; 4 hours) specifically and concentration-dependently upregulates the expression of MCP-1 and IL-8 mRNA in endothelial cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC cell
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Concentration:100, 250, 500, 1000 µg/mL
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Incubation Time:4h
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Result:Increased the MCP-1 from 1.3 times in the control group with 100 µg/mL to 3.1 times at 1000 µg/mL.
Increases IL-8 from 1.2 times in the control group with 100 µg/mL to 2.6 times at 1000 µg/mL.
Chemical Information
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CAS No. 9001-32-5
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Appearance Solid
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Color White to off-white
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SMILES
[Fibrinogen (Bovine)]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Foods
Glycosylation Remodeling and Thermal Denaturation Dictate the Functional Diversification of Protein Z. [Abstract]2026 Mar 4;15(5):853. PMID: 41829126 -
Microvasc Res
DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target. [Abstract]2025 Sep:161:104833. PMID: 40571189
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS) was used to construct the VMs 3D cell model with or without DDIT4 knockdown.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Vascular sprouting in the VMs 3D cell model after 7 days of culture.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the VMs 3D cell model.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the DDIT4 knockdown VMs 3D cell model.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Immunohistochemical (IHC) staining of DDIT4, phospho-p65, and VEGFA in the LPS-stimulated DDIT4 knockdown VMs 3D cell model was performed.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (394 KB)
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- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Tyagi N, et al.Fibrinogen induces endothelial cell permeability. Mol Cell Biochem. 2008 Jan;307(1-2):13-22. [Content Brief]
[3]. Guo M, et al. Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004;92(4):858-866. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fibrinogen (Bovine) Related Classifications
HY-125864 Related Classifications
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