Fibrinogen (Bovine)
Based on 2 publication(s) in Google Scholar
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 9001-32-5
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Fibrinogen (Bovine)
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2D/3D Cell Culture and Differentiation
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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Histological Imaging/Staining
Biological Activity
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IL-8 |
p50 |
p65 |
c-Rel |
Fibrinogen (0.3, 2, 4 mg/mL; 30 min) can induce a dose-dependent increase in the permeability of the endothelial cell layer to albumin, leading to the formation of gaps between endothelial cells and consequent albumin leakage[2].
Fibrinogen (2, 4 mg/mL; 1, 6, 12, 24 hours) increases leakage through the endothelial cell monolayer with time and dose[2].
Fibrinogen (4 mg/mL; 30 min) causes a dose-dependent increase in F-actin formation as well as gap formation in the endothelial cell monolayer[2].
Fibrinogen (2, 4 mg/mL; 30 min) can trigger a dose-dependent increase in ERK phosphorylation[2].
Fibrinogen (1000 µg/ml, 4 hours) can regulate the activation of NF-κB in endothelial cells (HUVEC) and specifically bind with the subunits p50, p65, c-Rel[3].
Fibrinogen (250 µg/mL, 4 hours) induces the activation of NF-κB, which is independent of Polybacterial B (HY-K1044) (5 µg/ml) and IL-1β (HY-P80503) (5 µg/ml)[3]
Fibrinogen (100, 250, 500, 1000 µg/mL; 4 hours) specifically and concentration-dependently upregulates the expression of MCP-1 and IL-8 mRNA in endothelial cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC cell
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Concentration:100, 250, 500, 1000 µg/mL
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Incubation Time:4h
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Result:Increased the MCP-1 from 1.3 times in the control group with 100 µg/mL to 3.1 times at 1000 µg/mL.
Increases IL-8 from 1.2 times in the control group with 100 µg/mL to 2.6 times at 1000 µg/mL.
Chemical Information
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CAS No. 9001-32-5
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Appearance Solid
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Color White to off-white
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SMILES
[Fibrinogen (Bovine)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Foods
Glycosylation Remodeling and Thermal Denaturation Dictate the Functional Diversification of Protein Z. [Abstract]2026 Mar 4;15(5):853. PMID: 41829126 -
Microvasc Res
DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target. [Abstract]2025 Jun 24:104833. PMID: 40571189
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS) was used to construct the VMs 3D cell model with or without DDIT4 knockdown.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Vascular sprouting in the VMs 3D cell model after 7 days of culture.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the VMs 3D cell model.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the DDIT4 knockdown VMs 3D cell model.
Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Immunohistochemical (IHC) staining of DDIT4, phospho-p65, and VEGFA in the LPS-stimulated DDIT4 knockdown VMs 3D cell model was performed.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[2]. Tyagi N, et al.Fibrinogen induces endothelial cell permeability. Mol Cell Biochem. 2008 Jan;307(1-2):13-22. [Content Brief]
[3]. Guo M, et al. Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004;92(4):858-866. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fibrinogen (Bovine) Related Classifications
HY-125864 Related Classifications
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