Fibrinogen (Bovine)

Name: Fibrinogen (Bovine)
Brand: MedChemExpress
SKU: HY-125864
Rating: 5.0 (2 reviews)

Cat. No.: HY-125864: Data Sheet
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Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases.

For research use only. We do not sell to patients.

CAS No. : 9001-32-5

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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Fibrinogen (Bovine)

2D/3D Cell Culture and Differentiation

Cell Imaging/Staining

Histological Imaging/Staining

: Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]; Fibrinogen (2 mg/mL; DPBS) was used to construct the VMs 3D cell model with or without DDIT4 knockdown.

: Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]; Fibrinogen (2 mg/mL; DPBS). Vascular sprouting in the VMs 3D cell model after 7 days of culture.

: Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]; Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the VMs 3D cell model.

: Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]; Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the DDIT4 knockdown VMs 3D cell model.

: Fibrinogen (Bovine) purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Jun 24:104833. [Abstract]; Fibrinogen (2 mg/mL; DPBS). Immunohistochemical (IHC) staining of DDIT4, phospho-p65, and VEGFA in the LPS-stimulated DDIT4 knockdown VMs 3D cell model was performed.

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IL-8

p50

p65

c-Rel

In Vitro

Fibrinogen (0.3, 2, 4 mg/mL; 30 min) can induce a dose-dependent increase in the permeability of the endothelial cell layer to albumin, leading to the formation of gaps between endothelial cells and consequent albumin leakage^[2].
Fibrinogen (2, 4 mg/mL; 1, 6, 12, 24 hours) increases leakage through the endothelial cell monolayer with time and dose^[2].
Fibrinogen (4 mg/mL; 30 min) causes a dose-dependent increase in F-actin formation as well as gap formation in the endothelial cell monolayer^[2].
Fibrinogen (2, 4 mg/mL; 30 min) can trigger a dose-dependent increase in ERK phosphorylation^[2].
Fibrinogen (1000 µg/ml, 4 hours) can regulate the activation of NF-κB in endothelial cells (HUVEC) and specifically bind with the subunits p50, p65, c-Rel^[3]. Fibrinogen (250 µg/mL, 4 hours) induces the activation of NF-κB, which is independent of Polybacterial B (HY-K1044) (5 µg/ml) and IL-1β (HY-P80503) (5 µg/ml)^[3] Fibrinogen (100, 250, 500, 1000 µg/mL; 4 hours) specifically and concentration-dependently upregulates the expression of MCP-1 and IL-8 mRNA in endothelial cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:	HUVEC cell
Concentration:	100, 250, 500, 1000 µg/mL
Incubation Time:	4h
Result:	Increased the MCP-1 from 1.3 times in the control group with 100 µg/mL to 3.1 times at 1000 µg/mL. Increases IL-8 from 1.2 times in the control group with 100 µg/mL to 2.6 times at 1000 µg/mL.

CAS No.

9001-32-5

Appearance

Solid

Color

White to off-white

SMILES

[Fibrinogen (Bovine)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (230 KB)

Handling Instructions (2659 KB)

References

[1]. Brown JH, et al. The crystal structure of modified bovine fibrinogen. Proc Natl Acad Sci U S A. 2000;97(1):85-90.

[2]. Tyagi N, et al.Fibrinogen induces endothelial cell permeability. Mol Cell Biochem. 2008 Jan;307(1-2):13-22. [Content Brief]

[3]. Guo M, et al. Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004;92(4):858-866. [Content Brief]