Murine Fibrinogen
Based on 2 publication(s) in Google Scholar
Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 9001-32-5
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-D0842A
BSA Protein (Low Endotoxin,Fatty acid free) -
HY-D0842
BSA Protein -
HY-W250978
Ovalbumins -
HY-P1956
HSA Protein -
HY-125864
Fibrinogen (Bovine) -
HY-NP010
Type I Collagen, from rat tail -
HY-P2995
Hemoglobin -
HY-P2738
Collagen, Type I, from bovine achilles tendon -
HY-NP003
Collagen, Type II, from bovine snout membrane -
HY-W250978A
Ovalbumin, low endotoxin -
HY-125865
Casein -
HY-P1956A
HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg)
Publications Citing Use of MedChemExpress (MCE) Murine Fibrinogen
More
Customer Validation & Images
-
2D/3D Cell Culture and Differentiation
-
Cell Imaging/Staining
-
Cell Imaging/Staining
-
Cell Imaging/Staining
-
Histological Imaging/Staining
Activité biologique
Description
IC50 & Target
[1]|
MMP-9 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (12-week-old male, 26-30 g, wild-type); MMP9-/- (FVB.Cg-Mmp9tm1Tvu/J, 12-week-old male, 26-30 g, MMP-9 gene knockout); FVB/NJ (12-week-old male, 26-30 g, wild-type)[1]
-
Dosage:20 mg per 100 g of body weight (resulting in a blood concentration of 4 mg/mL)
-
Administration:carotid artery infusion; 20 mL/min; 10 minutes
-
Result:Induced significantly greater pial venular macromolecular leakage (fluorescence intensity of 155 FIU) than PBS infusion in wild-type C57BL/6J mice.
Increased endothelial ICAM-1 expression to 50 FIU (vs 22 FIU with PBS) in wild-type C57BL/6J mice.
Reduced VE-cadherin expression to 22 FIU (vs 43 FIU with PBS) in wild-type C57BL/6J mice.
Increased MMP activity to 71 FIU in wild-type C57BL/6J mice.
Increased PV-1 expression to 170 FIU (vs 50 FIU with PBS) in wild-type C57BL/6J mice.
Induced further increased pial venular leakage (fluorescence intensity of 182 FIU) when combined with topical histamine in wild-type C57BL/6J mice.
Induced significantly greater pial venular macromolecular leakage (fluorescence intensity of 137 FIU) than PBS infusion in MMP9-/- mice, but less leakage than in wild-type mice.
Increased endothelial ICAM-1 expression to 39 FIU (vs 24 FIU with PBS) in MMP9-/- mice.
Reduced VE-cadherin expression to 28 FIU (vs 78 FIU with PBS) in MMP9-/- mice, with higher VE-cadherin levels than in Fg-treated wild-type mice.
Increased MMP activity to 46 FIU in MMP9-/- mice, with lower activity than in Fg-treated wild-type mice.
Increased PV-1 expression to 75 FIU (vs 50 FIU with PBS) in MMP9-/- mice, with lower expression than in Fg-treated wild-type mice.
Induced further increased pial venular leakage (fluorescence intensity of 152 FIU) when combined with topical histamine in MMP9-/- mice, but less leakage than in histamine-exposed, Fg-treated wild-type mice.
Induced pial venular macromolecular leakage (fluorescence intensity of 152 FIU) comparable to that in Fg-treated wild-type mice in FVB/NJ mice, with significantly greater leakage than PBS infusion.
Induced further increased pial venular leakage (fluorescence intensity of 178 FIU) when combined with topical histamine in FVB/NJ mice, comparable to that in histamine-exposed, Fg-treated wild-type mice.
Showed no degradation post-infusion.
Chemical Information
-
CAS No. 9001-32-5
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Murine Fibrinogen]
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Foods
Glycosylation Remodeling and Thermal Denaturation Dictate the Functional Diversification of Protein Z. [Abstract]2026 Mar 4;15(5):853. PMID: 41829126 -
Microvasc Res
DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target. [Abstract]2025 Sep:161:104833. PMID: 40571189
Murine Fibrinogen purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS) was used to construct the VMs 3D cell model with or without DDIT4 knockdown.
Murine Fibrinogen purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Vascular sprouting in the VMs 3D cell model after 7 days of culture.
Murine Fibrinogen purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the VMs 3D cell model.
Murine Fibrinogen purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Time-lapse analysis on days 7, 9, and 11 showed the angiogenesis rate in the DDIT4 knockdown VMs 3D cell model.
Murine Fibrinogen purchased from MedChemExpress. Usage Cited in: Microvasc Res. 2025 Sep:161:104833. [Abstract]
Fibrinogen (2 mg/mL; DPBS). Immunohistochemical (IHC) staining of DDIT4, phospho-p65, and VEGFA in the LPS-stimulated DDIT4 knockdown VMs 3D cell model was performed.
Pureté et documentation
-
Fiche technique (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Murine Fibrinogen Related Classifications
HY-125864B Related Classifications
Powered by Bioz