Rabbit Fibrinogen

Fibrinogen (0.3-4 mg/mL; 30 min) can induce a dose-dependent increase in the permeability of the endothelial cell layer to albumin, leading to the formation of gaps between endothelial cells and consequent albumin leakage^[2].
Fibrinogen (2-4 mg/mL; 1-24 hours) increases leakage through the endothelial cell monolayer with time and dose^[2].
Fibrinogen (4 mg/mL; 30 min) causes a dose-dependent increase in F-actin formation as well as gap formation in the endothelial cell monolayer^[2].
Fibrinogen (2-4 mg/mL; 30 min) can trigger a dose-dependent increase in ERK phosphorylation^[2].
Fibrinogen (1000 µg/ml, 4 hours) can regulate the activation of NF-κB in endothelial cells (HUVEC) and specifically bind with the subunits p50, p65, c-Rel^[3]. Fibrinogen (250 µg/mL, 4 hours) induces the activation of NF-κB, which is independent of Polybacterial B (HY-K1044) (5 µg/ml) and IL-1β (HY-P80503) (5 µg/ml)^[3] Fibrinogen (100-1000 µg/mL; 4 hours) specifically and concentration-dependently upregulates the expression of MCP-1 and IL-8 mRNA in endothelial cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.