1. GPCR/G Protein
  2. Leukotriene Receptor
  3. BIIL-260 hydrochloride

BIIL-260 hydrochloride 

Cat. No.: HY-114641A
Handling Instructions

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM.

For research use only. We do not sell to patients.

BIIL-260 hydrochloride Chemical Structure

BIIL-260 hydrochloride Chemical Structure

CAS No. : 192581-24-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 255 In-stock
Estimated Time of Arrival: December 31
1 mg USD 75 In-stock
Estimated Time of Arrival: December 31
5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Description

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].

IC50 & Target

Ki: 1.7 nM (LTB4 receptor)[1]

In Vitro

BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM

Molecular Weight

503.03

Formula

C₃₀H₃₁ClN₂O₃

CAS No.

192581-24-1

SMILES

N=C(C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1)N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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BIIL-260 hydrochloride
Cat. No.:
HY-114641A
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