BIIL-260 hydrochloride
Based on 1 publication(s) in Google Scholar
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 192581-24-1
- Formula: C30H31ClN2O3
- Molecular Weight:503.03
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BIIL-260 hydrochloride
MoreAll Leukotriene Receptor Isoforms
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Biological Activity
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LTB4 1.7 nM (Ki) |
BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 192581-24-1
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Appearance Solid
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Molecular Weight 503.03
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Formula C30H31ClN2O3
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Color White to off-white
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SMILES
N=C(C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1)N.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Leukoc Biol
Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]2025 Jul 9;117(7):qiaf082. PMID: 40476443
Solvent & Solubility
DMSO : 125 mg/mL (248.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9880 mL | 9.9398 mL | 19.8795 mL | 49.6988 mL |
| 5 mM | 0.3976 mL | 1.9880 mL | 3.9759 mL | 9.9398 mL | |
| 10 mM | 0.1988 mL | 0.9940 mL | 1.9880 mL | 4.9699 mL | |
| 15 mM | 0.1325 mL | 0.6627 mL | 1.3253 mL | 3.3133 mL | |
| 20 mM | 0.0994 mL | 0.4970 mL | 0.9940 mL | 2.4849 mL | |
| 25 mM | 0.0795 mL | 0.3976 mL | 0.7952 mL | 1.9880 mL | |
| 30 mM | 0.0663 mL | 0.3313 mL | 0.6627 mL | 1.6566 mL | |
| 40 mM | 0.0497 mL | 0.2485 mL | 0.4970 mL | 1.2425 mL | |
| 50 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9940 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3313 mL | 0.8283 mL | |
| 80 mM | 0.0248 mL | 0.1242 mL | 0.2485 mL | 0.6212 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4970 mL |
BIIL-260 hydrochloride Related Classifications
HY-114641A Related Classifications
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