2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. PF-07054894

PF-07054894 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease.

For research use only. We do not sell to patients.

PF-07054894 Chemical Structure

PF-07054894 Chemical Structure

CAS No. : 2413693-96-4

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1 mg USD 600 In-stock
5 mg USD 1500 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

PF-07054894 Related Antibodies

Top Publications Citing Use of Products

View All CCR Isoform Specific Products:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

PF-07054894 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease[1].

IC50 & Target[1]

CCR6

 

Clinical Trial
Molecular Weight

466.53

Formula

C24H30N6O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(C(N(C)C)=O)N=CC=C1NC2=C(N[C@@H](C3=NN(C)C=C3C)C4(C)CCCC4)C(C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7174 mL 21.4348 mL
5 mM 0.4287 mL 2.1435 mL 4.2870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1435 mL 10.7174 mL 21.4348 mL 53.5871 mL
5 mM 0.4287 mL 2.1435 mL 4.2870 mL 10.7174 mL
10 mM 0.2143 mL 1.0717 mL 2.1435 mL 5.3587 mL
15 mM 0.1429 mL 0.7145 mL 1.4290 mL 3.5725 mL
20 mM 0.1072 mL 0.5359 mL 1.0717 mL 2.6794 mL
25 mM 0.0857 mL 0.4287 mL 0.8574 mL 2.1435 mL
30 mM 0.0714 mL 0.3572 mL 0.7145 mL 1.7862 mL
40 mM 0.0536 mL 0.2679 mL 0.5359 mL 1.3397 mL
50 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0717 mL
60 mM 0.0357 mL 0.1786 mL 0.3572 mL 0.8931 mL
80 mM 0.0268 mL 0.1340 mL 0.2679 mL 0.6698 mL
100 mM 0.0214 mL 0.1072 mL 0.2143 mL 0.5359 mL
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PF-07054894 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-070548942413693-96-4PF07054894PF 07054894CCRCC chemokine receptorG protein-coupled receptorinflammatorybowelInhibitorinhibitorinhibit

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