1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Dovramilast

Dovramilast  (Synonyms: CC-11050)

Cat. No.: HY-147263
Handling Instructions

Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).

For research use only. We do not sell to patients.

Dovramilast Chemical Structure

Dovramilast Chemical Structure

CAS No. : 340019-69-4

Size Price Stock
5 mg USD 380 Ask For Quote & Lead Time
10 mg USD 600 Ask For Quote & Lead Time
25 mg USD 1150 Ask For Quote & Lead Time
50 mg USD 1800 Ask For Quote & Lead Time
100 mg USD 2850 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB)[1].

IC50 & Target

PDE4

 

In Vivo

Dovramilast (oral gavage, 5, 25, or 50 mg/kg, single) significantly improves antibiotic-mediated bacterial killing and reduces lung pathology[2].
Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice[2].

Sampling time(h) Concentration(ng/ml)
CC-11050 only CC-11050+INH
1 1,331.6±136.97 905.35±594.23
2 1,409.47±140.85 1,309.39±214.08
5 948.85±128.7 1,609.18±167.2
8 820.6±265.98 1,271.73±249.18
24 1.27±1.1 4.96±1.85
Tmax(h) 2.0 5.0
Cmax(ng/ml) 1,410 1,610
AUClast(ng × h/ml) 10,200 13,900

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6D2F1 mice[2]
Dosage: 5, 25, or 50 mg/kg
Administration: oral, 5, 25, or 50 mg/kg, single
Result: Reduced PDE4 expression in mtb-infected mouse lungs.
Animal Model: B6D2F1 mice[2]
Dosage: 5, 25, or 50 mg/kg
Administration: oral gavage, 5, 25, or 50 mg/kg, single
Result: Improved antibiotic-mediated bacterial killing and reduced lung pathology.
Clinical Trial
Molecular Weight

472.55

Formula

C24H28N2O6S

CAS No.
SMILES

O=C(C1CC1)NC2=CC=CC(CN3[[email protected]@H](C4=CC=C(OC)C(OCC)=C4)CS(=O)(C)=O)=C2C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dovramilast
Cat. No.:
HY-147263
Quantity:
MCE Japan Authorized Agent: