Cat. No.: HY-137976

Penehyclidine hydrochloride

(Synonyms: Penequinine hydrochloride)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.

For research use only. We do not sell to patients.

Purity: 99.2%
CAS No.: 151937-76-7
Formula: C₂₀H₃₀ClNO₂
Molecular Weight:351.91

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Penehyclidine hydrochloride Chemical Structure

CAS No.: 151937-76-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

mAChR1

mAChR3

NF-κB

All mAChR Isoforms :

All NF-κB Isoforms :

All Akt Isoforms :

All GSK-3 Isoforms :

All ERK Isoforms :

In Vitro

Penehyclidine (0.01-1.0 μM, 2 h) reduces the levels of IFN-γ, TNF-α, IL-1β, IL-6, promotes LPS (HY-D1056)-induced cell proliferation of BEAS-2B, inhibits the apoptosis, and promotes the LPS (HY-D1056)-induced autophagy in BEAS-2B^[2].
Penehyclidine (0.1 μM, 2 h) activates the Akt/GSK-3β signaling pathway, and alleviates the A/R-induced cell injury in H9c2 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

BEAS-2B
Concentration:

0.01-1.0 μM
Incubation Time:

2 h
Result:

Inhibited cell apoptosis.

Western Blot Analysis^[2]

Cell Line:

BEAS-2B
Concentration:

0.01-1.0 μM
Incubation Time:

2 h
Result:

Increased the expression of Bcl-2.

In Vivo

Penehyclidine (0.3-3 mg/kg, ip, single dose) exhibits protective activity in rats ALI models^[2].
Penehyclidine (1 mg/kg, ip, single dose) enhances the expression of BDNF and phosphorylation of ERK1/2 in the hippocampus, exhibits antidepressant-like effects in mouse CUMS model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

rats ALI models^[2]
Dosage:

0.3-3 mg/kg
Administration:

ip, single dose
Result:

Alleviated LPS-induced lung injury in rats.

Animal Model:

Mouse chronic unpredictable mild stress (CUMS) model^[4]
Dosage:

1 mg/kg
Administration:

ip, single dose
Result:

Reduced the immobility time in the forced swimming test (FST) and tail suspension test (TST).

Chemical Information

CAS No. 151937-76-7
Appearance Solid
Molecular Weight 351.91
Formula C₂₀H₃₀ClNO₂
Color White to off-white
SMILES

OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl
Synonyms

Penequinine hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

J Pharm Biomed Anal

Study on the mechanism of action of Penehyclidine hydrochloride on LPS-induced acute lung injury by regulating autophagy through the mTOR/Keap1/Nrf2 signaling pathway. [Abstract]

2025 Sep 15:263:116938. PMID: 40306137

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (355.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (284.16 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8416 mL

14.2082 mL

28.4164 mL

5 mM

0.5683 mL

2.8416 mL

5.6833 mL

10 mM

0.2842 mL

1.4208 mL

2.8416 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. [Content Brief]

[2]. Wang X, et al., Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway. Mol Med Rep. 2021 Feb;23(2):100. [Content Brief]

[3]. Zi C, et al., Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362. [Content Brief]

[4]. Sun X, et al., A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44(12):2723-2732. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.8416 mL	14.2082 mL	28.4164 mL	71.0409 mL
	5 mM	0.5683 mL	2.8416 mL	5.6833 mL	14.2082 mL
	10 mM	0.2842 mL	1.4208 mL	2.8416 mL	7.1041 mL
	15 mM	0.1894 mL	0.9472 mL	1.8944 mL	4.7361 mL
	20 mM	0.1421 mL	0.7104 mL	1.4208 mL	3.5520 mL
	25 mM	0.1137 mL	0.5683 mL	1.1367 mL	2.8416 mL
	30 mM	0.0947 mL	0.4736 mL	0.9472 mL	2.3680 mL
	40 mM	0.0710 mL	0.3552 mL	0.7104 mL	1.7760 mL
	50 mM	0.0568 mL	0.2842 mL	0.5683 mL	1.4208 mL
	60 mM	0.0474 mL	0.2368 mL	0.4736 mL	1.1840 mL
	80 mM	0.0355 mL	0.1776 mL	0.3552 mL	0.8880 mL
	100 mM	0.0284 mL	0.1421 mL	0.2842 mL	0.7104 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Penehyclidine hydrochloride

1 Cited Publications

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Penehyclidine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) Penehyclidine hydrochloride

All mAChR Isoforms

All NF-κB Isoforms

All Akt Isoforms

All GSK-3 Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Penehyclidine hydrochloride Related Classifications

HY-137976 Related Classifications