Andrograpanin
Based on 1 publication(s) in Google Scholar
Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 82209-74-3
- Formula: C20H30O3
- Molecular Weight:318.45
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Andrograpanin
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | GI50 |
20.01 μM
Compound: 6
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Antiproliferative activity against human HL60 cells by trypan blue assay
Antiproliferative activity against human HL60 cells by trypan blue assay
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[PMID: 18357994] |
| RAW264.7 | IC50 |
11.6 μM
Compound: 25
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
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[PMID: 22264489] |
Andrograpanin exhibits anti-inflammatory properties in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways[1].Andrograpanin enhances chemokine SDF-1α-induced leukocytes chemotaxis in Jurkat, THP-1 and PBL cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 82209-74-3
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Appearance Solid
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Molecular Weight 318.45
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Formula C20H30O3
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Color White to off-white
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SMILES
O=C1OCC=C1CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)CCC[C@@]23C)=C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Harmonizing international quality standards for Andrographis paniculata: A comparative analysis of content determination methods across pharmacopeias. [Abstract]2024 Mar 15:240:115924. PMID: 38142499
Solvent & Solubility
DMSO : 100 mg/mL (314.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. 1.Li-Li Ji, et al.Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. J Cell Biochem. 2005 Aug 1;95(5):970-8. [Content Brief]
[2]. 2.Jun Liu, et al. Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways. Int Immunopharmacol. 2008 Jul;8(7):951-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1402 mL | 15.7011 mL | 31.4021 mL | 78.5053 mL |
| 5 mM | 0.6280 mL | 3.1402 mL | 6.2804 mL | 15.7011 mL | |
| 10 mM | 0.3140 mL | 1.5701 mL | 3.1402 mL | 7.8505 mL | |
| 15 mM | 0.2093 mL | 1.0467 mL | 2.0935 mL | 5.2337 mL | |
| 20 mM | 0.1570 mL | 0.7851 mL | 1.5701 mL | 3.9253 mL | |
| 25 mM | 0.1256 mL | 0.6280 mL | 1.2561 mL | 3.1402 mL | |
| 30 mM | 0.1047 mL | 0.5234 mL | 1.0467 mL | 2.6168 mL | |
| 40 mM | 0.0785 mL | 0.3925 mL | 0.7851 mL | 1.9626 mL | |
| 50 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5701 mL | |
| 60 mM | 0.0523 mL | 0.2617 mL | 0.5234 mL | 1.3084 mL | |
| 80 mM | 0.0393 mL | 0.1963 mL | 0.3925 mL | 0.9813 mL | |
| 100 mM | 0.0314 mL | 0.1570 mL | 0.3140 mL | 0.7851 mL |
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