1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Leonurine (Synonyms: SCM-198)

Cat. No.: HY-N0741 Purity: 99.45%
Handling Instructions

Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect.

For research use only. We do not sell to patients.
Leonurine Chemical Structure

Leonurine Chemical Structure

CAS No. : 24697-74-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
5 mg USD 60 In-stock
10 mg USD 90 In-stock
25 mg USD 190 In-stock
50 mg USD 360 In-stock
100 mg USD 590 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Leonurine:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect.

In Vitro

Leonurine can obviously attenuate the spontaneous excitatory postsynaptic current amplitude and frequency on pyramidal neurons[1]. Leonurine can dose-dependently suppress PI glycation. Leonurine may inhibit PI glycation through trapping MGO and keeping it from reacting with PI[2]. Leonurine can dose-dependently suppress PI glycation[3].

In Vivo

Leonurine (60 mg/kg/day)+2-VO significantly decreases levels of glutamate and hydrogen peroxide, improves both the cognitive flexibility and the spatial learning and memory abilities. Moreover, leonurine obviously enhances long-term depression, elevates the ratio of N-methyl-D-aspartate receptor 2A/2B, and decreases the expression of postsynaptic density protein-95. Interestingly, the ratio of LC3II/LC3I and beclin-1 expression are markedly down-regulated by leonurine[1]. Leonurine significantly alleviates LPS-induced histopathological changes, downregulates the levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), upregulates the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse mastitis model. Leonurine inhibits the expression of Toll-like receptor 4 (TLR4) and the activation of nuclear factor-kappaB (NF-κB) and the phosphorylation of p38, extracellular signal-regulated kinase (ERK), and Jun N-terminal kinase (JNK)[4].

Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6 mg/mL (Need ultrasonic)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.45%

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