2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. Tetramethylcurcumin

Tetramethylcurcumin  (Synonyms: FLLL31)

Cat. No.: HY-N2521 Purity: 99.91%
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Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects.

For research use only. We do not sell to patients.

Tetramethylcurcumin Chemical Structure

Tetramethylcurcumin Chemical Structure

CAS No. : 52328-97-9

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5 mg USD 120 In-stock
10 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

Tetramethylcurcumin Related Antibodies

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Description

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].

IC50 & Target[1]

STAT3

 

In Vitro

Tetramethylcurcumin (FLLL31; 2.5 and 5 µM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells[1].
Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetramethylcurcumin Related Antibodies
Molecular Weight

424.49

Formula

C25H28O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=C(C=CC(/C=C/C(C(C)(C)C(/C=C/C2=CC(OC)=C(OC)C=C2)=O)=O)=C1)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

COA (245 KB) HNMR (100 KB) RP-HPLC (217 KB) MS (83 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3558 mL 11.7788 mL 23.5577 mL 58.8942 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL 11.7788 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL 5.8894 mL
15 mM 0.1571 mL 0.7853 mL 1.5705 mL 3.9263 mL
20 mM 0.1178 mL 0.5889 mL 1.1779 mL 2.9447 mL
25 mM 0.0942 mL 0.4712 mL 0.9423 mL 2.3558 mL
30 mM 0.0785 mL 0.3926 mL 0.7853 mL 1.9631 mL
40 mM 0.0589 mL 0.2945 mL 0.5889 mL 1.4724 mL
50 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1779 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9816 mL
80 mM 0.0294 mL 0.1472 mL 0.2945 mL 0.7362 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
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Tetramethylcurcumin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetramethylcurcumin52328-97-9FLLL31FLLL 31FLLL-31STATApoptosisCurcuminJanuskinase2Srchomology-2domainanti-inflammatorypancreaticbreastcancerInhibitorinhibitorinhibit

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