Cat. No.: HY-N0214A

Peimisine hydrochloride

(Synonyms: Ebeiensine hydrochloride)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research.

For research use only. We do not sell to patients.

Purity: 99.34%
CAS No.: 900498-44-4
Formula: C₂₇H₄₂ClNO₃
Molecular Weight:464.08

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Peimisine hydrochloride Chemical Structure

CAS No.: 900498-44-4

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (3)
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References
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Biological Activity

Description

All mAChR Isoforms :

In Vitro

Peimisine (17.43-92.07 μg/mL; 72 h) shows significant cytotoxic effects^[3].
Peimisine (15 μg/mL; 24, 48 and 72 h) induces G₀/G₁ phase arrest and rising apoptosis rate^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

A2780 cells
Concentration:

15 μg/mL
Incubation Time:

24, 48 and 72 hours
Result:

Induced G₀/G₁ phase arrest of A2780 cells in a time-dependent manner.

Cell Cytotoxicity Assay^[2]

Cell Line:

LLC, A2780, HepG2 and A549 cells
Concentration:

17.43-92.07 μg/mL
Incubation Time:

72 hours
Result:

Inhibited LLC, A2780, HepG2 and A549 cells with the IC₅₀ values of 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL, respectively.

Chemical Information

CAS No. 900498-44-4
Appearance Solid
Molecular Weight 464.08
Formula C₂₇H₄₂ClNO₃
Color White to off-white
SMILES

CC1=C(C[C@@]2([H])[C@@]3([H])CC([C@]4([H])[C@@]2(CC[C@@H](C4)O)C)=O)[C@@]3([H])CC[C@]15O[C@@]6([H])[C@](NC[C@H](C6)C)([H])[C@H]5C.[H]Cl
Synonyms

Ebeiensine hydrochloride
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (3)

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Phytomedicine

Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway. [Abstract]

2023 Sep:118:154946. PMID: 37421766
Molecules

Metabolite Profiling and Anti-Inflammatory Activities of Fritillaria cirrhosa D. Don Bulbs Derived from Tissue Culture. [Abstract]

2025 Jan 31;30(3):623. PMID: 39942727
J Pharm Pharmacol

Peimisine ameliorates DSS-induced colitis by suppressing Jak-Stat activation and alleviating gut microbiota dysbiosis in mice. [Abstract]

2024 May 3;76(5):545-558. PMID: 38007392

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pan F, et al. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine. 2014 Jul-Aug;21(8-9):1104-9. [Content Brief]

[2]. Armando Alberola-Die, et al. Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts, Modulates Muscle-Type Nicotinic Receptors. Int J Mol Sci. 2021 Oct 19;22(20):11287. [Content Brief]

[3]. Dongdong Wang, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC Complement Altern Med. 2015 Feb 21;15:29. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Peimisine hydrochloride

3 Cited Publications

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Peimisine hydrochloride

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All mAChR Isoforms

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Publications (3)

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References

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Peimisine hydrochloride Related Classifications

HY-N0214A Related Classifications