1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. Lipoxygenase
    Leukotriene Receptor
  3. 5-O-Demethylnobiletin

5-O-Demethylnobiletin (Synonyms: 5-Demethylnobiletin)

Cat. No.: HY-N1942 Purity: >99.0%
Handling Instructions

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM.

For research use only. We do not sell to patients.

5-O-Demethylnobiletin Chemical Structure

5-O-Demethylnobiletin Chemical Structure

CAS No. : 2174-59-6

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5 mg USD 158 In-stock
Estimated Time of Arrival: December 31
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20 mg USD 457 In-stock
Estimated Time of Arrival: December 31
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Description

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].

IC50 & Target[1]

LTC4

0.35 μM (IC50)

5-LOX

0.1 μM (IC50)

In Vitro

5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2].

Molecular Weight

388.37

Formula

C₂₀H₂₀O₈

CAS No.

2174-59-6

SMILES

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: >99.0%

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Keywords:

5-O-Demethylnobiletin5-DemethylnobiletinLipoxygenaseLeukotriene ReceptorLOXInhibitorinhibitorinhibit

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5-O-Demethylnobiletin
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HY-N1942
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