2174-59-6
Chemical Structure
5-O-Demethylnobiletin
Synonym(s): 5-Demethylnobiletin
- CAS No.: 2174-59-6
- Formula:C20H20O8
- Molecular Weight:388.37
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one
InChIKey: DOFJNFPSMUCECH-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
Biological Activity: 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
5-O-Demethylnobiletin | 99.91% | 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5-O-Demethylnobiletin (Standard) | ≥98% | 5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.91
HY-N197807-Hydroxy-5,6,8,3',4'-pentamethoxyflavone -
Similarity Score 0.89
HY-N12734Pebrellin -
Similarity Score 0.89
HY-N118148-Methoxycirsilineol -
Similarity Score 0.88
HY-N12735Hymenoxin -
Similarity Score 0.88
HY-N10078Gardenin D -
Similarity Score 0.88
HY-N0155Nobiletin -
Similarity Score 0.87
HY-N127925,8-Dihydroxy-3',4',6,7-tetramethoxyflavone -
Similarity Score 0.86
HY-N8303Gardenin A -
Similarity Score 0.85
HY-N11106Gardenin C -
Explore the MedChemAI to find more analogs
