1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. HIF/HIF Prolyl-Hydroxylase
    Reactive Oxygen Species
    Endogenous Metabolite
  3. AKBA

AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid)

Cat. No.: HY-N0892 Purity: 99.93%
Handling Instructions

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

For research use only. We do not sell to patients.

AKBA Chemical Structure

AKBA Chemical Structure

CAS No. : 67416-61-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 176 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 276 In-stock
Estimated Time of Arrival: December 31
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Description

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE)[1].
AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis[3].
AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon[1].
AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin[3].
AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.72

Formula

C32H48O5

CAS No.
SMILES
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 5.2 mg/mL (10.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9504 mL 9.7519 mL 19.5038 mL
5 mM 0.3901 mL 1.9504 mL 3.9008 mL
10 mM 0.1950 mL 0.9752 mL 1.9504 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.93%

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AKBA
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