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Cat. No.: HY-N3480

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Isogosferol

(Synonyms: (+)-Isogospherol; Isogospherol)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.

For research use only. We do not sell to patients.

CAS No.: 53319-52-1
Formula: C₁₆H₁₄O₅
Molecular Weight:286.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Isogosferol Chemical Structure

CAS No.: 53319-52-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Isogosferol (100, 200 µM; 1+16 h) decreases LPS (HY-D1056)-stimulated NO expression in RAW 264.7 cells^[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) decreases LPS-stimulated expression of iNOS, COX-2 protein in a dose-dependent manner^[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) decreases the LPS-stimulated expression of NF-κB and pERK1/2 in a dose-dependentmanner^[1].
Isogosferol (50, 100, 200 µM µM; 1+16 h) decreases LPS-stimulated release of the pro-inflammatory cytokine, IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW 264.7 cells
Concentration:

100, 200 µM (stimulated with LPS (1 µg/mL))
Incubation Time:

1+16
Result:

Remarkably down-regulated the LPS-stimulated NO expression with an IC₅₀ of 148 μM and shows no effect on cell viability.

Western Blot Analysis^[1]

Cell Line:

0, 25, 50, 100, 200 µM
Concentration:

1+16
Incubation Time:

1+16
Result:

Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner.

Chemical Information

CAS No. 53319-52-1
Molecular Weight 286.28
Formula C₁₆H₁₄O₅
SMILES

CC([C@@H](O)COC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O)=C
Synonyms

(+)-Isogospherol; Isogospherol
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
- Plants
- Umbelliferae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

bioRxiv

2023 Jun 15.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song HY, et al. Anti-Inflammatory Activities of Isogosferol, a Furanocoumarin Isolated from Citrus junos Seed Shells through Bioactivity-Guided Fractionation. Molecules. 2019 Nov 12;24(22):4088. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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