Cat. No.: HY-N1957

Gamma-Mangostin

(Synonyms: γ-Mangostin)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes.

For research use only. We do not sell to patients.

Purity: 99.91%
CAS No.: 31271-07-5
Formula: C₂₃H₂₄O₆
Molecular Weight:396.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Gamma-Mangostin Chemical Structure

CAS No.: 31271-07-5

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer^[2]. Gamma-Mangostin inhibits [3^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target^[1]

5-HT_2A Receptor

COX-2

All 5-HT Receptor Isoforms :

All COX Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	5.92 μM Compound: 3, gama-mangostin	Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
HepG2	IC₅₀	>10 μM Compound: 12	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 24960143]
HL-60	IC₅₀	6.1 μM Compound: 3	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test	[PMID: 12932141]
HT-29	ED₅₀	4 μM Compound: 4	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 21428375]
HT-29	IC₅₀	>10 μM Compound: 4	Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay	[PMID: 21428375]
L02	IC₅₀	>10 μM Compound: 12	Cytotoxicity against human HL7702 cells by MTT assay Cytotoxicity against human HL7702 cells by MTT assay	[PMID: 24960143]
MCF7	IC₅₀	>10 μM Compound: 12	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 24960143]
MDA-MB-231	IC₅₀	5.87 μM Compound: 3, gama-mangostin	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
MDA-MB-231	IC₅₀	6.6 μM Compound: 12	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 24960143]
NCI-H1299	EC₅₀	2.2 μM Compound: 2a	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation	[PMID: 33513389]
NCI-H460	IC₅₀	4.48 μM Compound: 3, gama-mangostin	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
RAW264.7	IC₅₀	>50 μM Compound: 12	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production	[PMID: 24960143]
SK-BR-3	IC₅₀	25.99 μM Compound: 9	Cytotoxicity against human SKBR3 cells assessed as survival by MTT assay Cytotoxicity against human SKBR3 cells assessed as survival by MTT assay	[PMID: 18558747]
SK-BR-3	IC₅₀	4.97 μM Compound: 9	Inhibition of aromatase over-expressed in human SKBR3 cells Inhibition of aromatase over-expressed in human SKBR3 cells	[PMID: 18558747]
SW-620	IC₅₀	5.69 μM Compound: 3, gama-mangostin	Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]

In Vitro

Gamma-Mangostin (0.5, 2.5, 5 μM; 2 hours) as an insulin sensitizer, alleviates hyperglycemia and is nontoxic to both vascular smoothing cells isolated from the external carotid artery in SD rats and FL83B mouse hepatocytes^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[5]

Cell Line:

vascular smoothing cells isolated from the external carotid artery of SD rats and liver cells of FL83B mice
Concentration:

0.5, 2.5, 5 μM
Incubation Time:

2h
Result:

Was not toxic to either cell line.
5 μM hypoglycemic effect was better than 0.5 and 2.5 μM.
In combination with insulin, reached a plateau in its synergistic effect on glucose uptake within 90 minutes.

In Vivo

Gamma-Mangostin (0.5, 1, 2 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and ameliorates damaged hepatocytes, primarily swelling, hydropic changes, and necrotic cells in the streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetic BALB/C mouse model^[3].
Gamma-Mangostin (1, 2, 4 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces blood urea nitrogen (BUN) and creatinine in plasma, and ameliorates the damage to renal proximal tubular cells in BALB/C mice with streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetes^[4].
Gamma-Mangostin (0.1, 0.2, 0.4 mg; Oral gavage (p.o.); 4 weeks) can reduce fasting blood glucose levels and oral glucose tolerance tests in diabetic ICR mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

STZ (HY-13753) (30 mg/kg)-induced BALB/C diabetic mouse model^[3]
Dosage:

0.5 mg/kg, 1 mg/kg, 2 mg/kg
Administration:

Oral gavage (p.o.); 14 days
Result:

Significantly reduced fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamate-pyruvate transaminase (SGPT) in diabetic mice.
Improved damaged liver cells, primarily those exhibiting swelling, water accumulation, and cell necrosis.

Chemical Information

CAS No. 31271-07-5
Appearance Solid
Molecular Weight 396.43
Formula C₂₃H₂₄O₆
Color Light yellow to yellow
SMILES

O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
Synonyms

γ-Mangostin
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Nat Commun

Discovery of senolytics using machine learning. [Abstract]

2023 Jun 10;14(1):3445. PMID: 37301862
Sep Purif Technol

2025 Jul 30.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5225 mL

12.6126 mL

25.2251 mL

5 mM

0.5045 mL

2.5225 mL

5.0450 mL

10 mM

0.2523 mL

1.2613 mL

2.5225 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31. [Content Brief]

[2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570. [Content Brief]

[3]. Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031

[4]. Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14(3): 1251-1256.

[5]. Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5225 mL	12.6126 mL	25.2251 mL	63.0628 mL
	5 mM	0.5045 mL	2.5225 mL	5.0450 mL	12.6126 mL
	10 mM	0.2523 mL	1.2613 mL	2.5225 mL	6.3063 mL
	15 mM	0.1682 mL	0.8408 mL	1.6817 mL	4.2042 mL
	20 mM	0.1261 mL	0.6306 mL	1.2613 mL	3.1531 mL
	25 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5225 mL
	30 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1021 mL
	40 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5766 mL
	50 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.2613 mL
	60 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0510 mL
	80 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
	100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.6306 mL

Keywords

Gamma-Mangostin

2 Cited Publications

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Gamma-Mangostin

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Publications Citing Use of MedChemExpress (MCE) Gamma-Mangostin

All 5-HT Receptor Isoforms

All COX Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Gamma-Mangostin Related Classifications

Cat. No.: HY-N1957