1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Gamma-Mangostin

Gamma-Mangostin (Synonyms: γ-Mangostin)

Cat. No.: HY-N1957
Handling Instructions

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) .

For research use only. We do not sell to patients.

Gamma-Mangostin Chemical Structure

Gamma-Mangostin Chemical Structure

CAS No. : 31271-07-5

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Description

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1].

IC50 & Target

5-hydroxytryptamine 2A (5-HT2A) receptors[1]

Molecular Weight

396.43

Formula

C₂₃H₂₄O₆

CAS No.

31271-07-5

SMILES

O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gamma-Mangostinγ-Mangostin5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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