1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Phillyrin

Phillyrin 

Cat. No.: HY-N0482
Handling Instructions

Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities.

For research use only. We do not sell to patients.

Phillyrin Chemical Structure

Phillyrin Chemical Structure

CAS No. : 487-41-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 59 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1].

IC50 & Target

CYP1A2; CYP2D1[1]

In Vitro

Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1].
Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1].

RT-PCR[1]

Cell Line: Human HepG2 hepatocyte cells
Concentration: 1 μM; 2.5 μM; 5 μM
Incubation Time: 24 hours
Result: Reduced FAS and SREBP-1c mRNA expression.
Molecular Weight

534.55

Formula

C₂₇H₃₄O₁₁

CAS No.

487-41-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (486.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8707 mL 9.3537 mL 18.7073 mL
5 mM 0.3741 mL 1.8707 mL 3.7415 mL
10 mM 0.1871 mL 0.9354 mL 1.8707 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PhillyrinCytochrome P450CYPsInhibitorinhibitorinhibit

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Phillyrin
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HY-N0482
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