2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TGFBR1-IN-1

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM.

For research use only. We do not sell to patients.

TGFBR1-IN-1 Chemical Structure

TGFBR1-IN-1 Chemical Structure

CAS No. : 2170830-26-7

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TGFBR1-IN-1 Related Antibodies

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Description

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1].

IC50 & Target[1]

ALK5

10-100 nM (IC50)

In Vitro

Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TGFBR1-IN-1 Related Antibodies
Molecular Weight

427.48

Formula

C23H17N5O2S
CAS No.
SMILES

O=C(C1=NN(C2=NC(C)=CC=C2)C(C3=CC=C4N=CSC4=C3)=C1)NC5=CC=C(O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TGFBR1-IN-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFBR1-IN-12170830-26-7TGF-β ReceptorTransforming growth factor beta receptorsALK5TGF-βfibroticdiseasetumorinflammatoryautoimmuneInhibitorinhibitorinhibit

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