1. TGF-beta/Smad
  2. TGF-β Receptor
  3. TGFBR1-IN-1

TGFBR1-IN-1 

Cat. No.: HY-129171
Handling Instructions

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM.

For research use only. We do not sell to patients.

TGFBR1-IN-1 Chemical Structure

TGFBR1-IN-1 Chemical Structure

CAS No. : 2170830-26-7

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Description

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1].

IC50 & Target

ALK5

10-100 nM (IC50)

In Vitro

Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1].

Molecular Weight

427.48

Formula

C₂₃H₁₇N₅O₂S

CAS No.

2170830-26-7

SMILES

O=C(C1=NN(C2=NC(C)=CC=C2)C(C3=CC=C4N=CSC4=C3)=C1)NC5=CC=C(O)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TGFBR1-IN-1TGF-β ReceptorTransforming growth factor beta receptorsALK5TGF-βfibroticdiseasetumorinflammatoryautoimmuneInhibitorinhibitorinhibit

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