1. Immunology/Inflammation
  2. COX NO Synthase
  3. COX-2/NO-IN-1

COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC50 of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects.

For research use only. We do not sell to patients.

COX-2/NO-IN-1 Chemical Structure

COX-2/NO-IN-1 Chemical Structure

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Description

COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC50 of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects[1].

In Vitro

COX-2/NO-IN-1 (Compound 13b; 2.5-10 μM) exhibits potent activity through dose-dependent inhibiting the production of nitric oxide (NO, IC50 = 3.52 μM), TNF-α and IL-6 (84.1% and 33.6%, respectively), as well as suppressing the expression of iNOS, COX-2 and TLR4 proteins in LPS-stimulated RAW264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In C57BL/6 mice with cisplatin-induced AKI, COX-2/NO-IN-1 (Compound 13b; 15-30 mg/kg; p.o.) improves kidney function, inhibits inflammatory development, and reduces pathological damage of kidney tissues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.28

Formula

C15H15NO3

SMILES

C=C(C(C1=CC2=CC=CC=C2N=C1)O)C(OCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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COX-2/NO-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
COX-2/NO-IN-1
Cat. No.:
HY-146161
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