Glucocorticoid receptor-IN-1

Cat. No.: HY-142941: Ficha de datos Instrucciones de manejo
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Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC₅₀ of 2.11 nM against hMMP1, and transcriptional activation activity with an EC₅₀ of 5.59 nM against MMTV.

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Glucocorticoid receptor-IN-1 Estructura química

No. CAS : 2662908-25-8

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Descripciòn	Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC₅₀ of 2.11 nM against hMMP1, and transcriptional activation activity with an EC₅₀ of 5.59 nM against MMTV^[1].
In Vitro	Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC₅₀ of 16.7 µM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Glucocorticoid receptor-IN-1 Related Antibodies
Peso molecular	513.45
Fòrmula	C₂₄H₁₉F₄N₇O₂
No. CAS	2662908-25-8
SMILES	CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=N5)C5=C2)=O
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (270 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Guoli Zhang, et al. Benzo[d][1,2,3]triazole ether compound. WO2021136431.