1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor MMP
  3. Glucocorticoid receptor-IN-1

Glucocorticoid receptor-IN-1 

Cat. No.: HY-142941
Handling Instructions

Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV.

For research use only. We do not sell to patients.

Glucocorticoid receptor-IN-1 Chemical Structure

Glucocorticoid receptor-IN-1 Chemical Structure

CAS No. : 2662908-25-8

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Description

Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].

In Vitro

Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC50 of 16.7 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

513.45

Formula

C24H19F4N7O2

CAS No.
SMILES

CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=N5)C5=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Glucocorticoid receptor-IN-1
Cat. No.:
HY-142941
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