2662908-25-8
Chemical Structure
Glucocorticoid receptor-IN-1
- CAS No.: 2662908-25-8
- Formula:C24H19F4N7O2
- Molecular Weight:513.45
IUPAC Name: N-((1R,2S)-1-((1-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-1H-benzo[d][1,2,3]triazol-5-yl)oxy)-1-(3,5-difluorophenyl)propan-2-yl)-2,2-difluoropropanamide
InChIKey: GOURWJGMMSVULR-XMHCIUCPSA-N
SMILES: CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=N5)C5=C2)=O
Biological Activity: Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].
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Glucocorticoid receptor-IN-1 | Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV. | |||||||||||||||||||||
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Keywords
