Coronarin A

Cat. No.: HY-N3628: FAQs
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Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research.

For research use only. We do not sell to patients.

Coronarin A Chemical Structure

CAS No. : 119188-33-9

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

mTORC1

S6K1

In Vitro

Coronarin A (3-30 μM; 4 or 12 h) stimulates glycogen synthesis through activating PI3K/Akt/GSK3β signaling and inhibits gluconeogenesis by activating ERK-dependent Wnt/β-catenin/TCF7L2 pathway in rat primary hepatocytes^[1].
Coronarin A (1-30 μM; 4 h) increases tyrosine phosphorylation of IRS1 through inhibiting mTOR/S6K1 signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Primary rat hepatocytes
Concentration:	1, 3, 10 and 30 μM
Incubation Time:	4 h
Result:	Increased the Akt and GSK3β phosphorylation dose-dependently. Dose-dependently stimulated the phosphorylation of both ERK1 and ERK2. Increased the phosphorylation of β-catenin and mitogen-activated protein kinase kinase (MEK). Dose-dependently enhanced the tyrosine phosphorylation of IRS1 at Tyr1222, whereas the serine phosphorylation of IRS1 was dose-dependently inhibited. Reduced the phosphorylation of mTOR, S6K1 and S6.

Cell Viability Assay^[1]

Cell Line:	Primary rat hepatocytes
Concentration:	1, 3, 10, 30, 100 and 300 μM
Incubation Time:	5.5 h or 12 h
Result:	Showed no toxicity at 1-30 μM, decreased cell viability after 12 h incubation at 100 μM.

In Vivo

Coronarin A (30 or 100 mg/kg; i.p. or p.o.; once daily for 22 days) ameliorates hyperglycemia in mice^[1].
Coronarin A (100 mg/kg; p.o.; once daily for 22 days) inhibits the mTOR/S6K1 pathway to activate PI3K/Akt and ERK/β-catenin signaling in livers of ob/ob mice^[1].
Pharmacokinetic properties of Coronarin A after single administration^a in ob/ob mice^[1].

Coronarin A	t_1/2 (h)	t_max (h)	C_max (ng/mL)	AUC_0-t (ng⋅h/mL)	AUC_0-∞ (ng⋅h/mL)	MRT (h)
i.p.	14.8	1.0	1073	4571	11045	21.7
p.o.	3.01	1.0	388	1694	1856	4.88

Data are presented as the mean of three mice.
^aCoronarin A was intraperitoneally or orally administered at 30 mg/kg to ob/ob mice.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ob/ob mice^[1]
Dosage:	30 mg/kg (IP) or 100 mg/kg (PO)
Administration:	Oral or intraperitoneal administration, once daily for 22 days
Result:	Significantly decreased the non-fasting and fasting blood glucose. Significantly reduced the serum insulin concentration at 15 min after glucose loading, reduced the average daily food intake while the body weight was unaffected. Increased hepatic glycogen content and the expression levels of gluconeogenic gene Pck1 and G6pc were significantly decreased.

Animal Model:	Female ob/ob mice^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal or oral administration (Pharmacokinetic Analysis)
Result:	Intraperitoneal injection exhibited higher plasma exposure than oral gavage at the same dose of 30 mg/kg, with C_max value of 1073 and 388 ng/mL, respectively.

Molecular Weight

300.44

Formula

C₂₀H₂₈O₂

CAS No.

119188-33-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@H]2/C=C/C3=COC=C3)[C@@](C(C)(CCC1)C)([H])C[C@H](O)C2=C

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9. [Content Brief]

Coronarin A Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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