1. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  2. GPR35 ERK
  3. Pamoic acid

Pamoic acid  (Synonyms: Embonic acid)

Cat. No.: HY-W008613 Purity: 98.63%
COA Handling Instructions

Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties.

For research use only. We do not sell to patients.

Pamoic acid Chemical Structure

Pamoic acid Chemical Structure

CAS No. : 130-85-8

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Based on 1 publication(s) in Google Scholar

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Description

Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].

IC50 & Target

EC50: 79 nM (GPR35)[1]

In Vitro

GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a mouse model of stroke, Pamoic acid (s.c.; 50-100 mg/kg) has neuroprotective activity that activates GPR35. Pharmacological inhibition of GPR35 reveals that Pamoic acid reduces infarcts size in a GPR35 dependent manner. Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with the reduced neutrophil counts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.38

Formula

C23H16O6

CAS No.
Unlabeled CAS

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5748 mL 12.8740 mL 25.7480 mL
5 mM 0.5150 mL 2.5748 mL 5.1496 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5748 mL 12.8740 mL 25.7480 mL 64.3699 mL
5 mM 0.5150 mL 2.5748 mL 5.1496 mL 12.8740 mL
10 mM 0.2575 mL 1.2874 mL 2.5748 mL 6.4370 mL
15 mM 0.1717 mL 0.8583 mL 1.7165 mL 4.2913 mL
20 mM 0.1287 mL 0.6437 mL 1.2874 mL 3.2185 mL
25 mM 0.1030 mL 0.5150 mL 1.0299 mL 2.5748 mL
30 mM 0.0858 mL 0.4291 mL 0.8583 mL 2.1457 mL
40 mM 0.0644 mL 0.3218 mL 0.6437 mL 1.6092 mL
50 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2874 mL
60 mM 0.0429 mL 0.2146 mL 0.4291 mL 1.0728 mL
80 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8046 mL
100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.6437 mL
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Pamoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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