1. Anti-infection Neuronal Signaling Membrane Transporter/Ion Channel
  2. Parasite nAChR Antibiotic
  3. Pyrantel pamoate

Pyrantel pamoate  (Synonyms: Pyrantel embonate)

Cat. No.: HY-12640 Purity: 99.98%
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Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.

For research use only. We do not sell to patients.

Pyrantel pamoate Chemical Structure

Pyrantel pamoate Chemical Structure

CAS No. : 22204-24-6

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Description

Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

IC50 & Target

Parasites[1][2].

In Vitro

Pyrantel pamoate (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A. suum
Concentration: 10 nM-10 µM
Incubation Time: 72 h
Result: Inhibited A. suum with a pEC50 value of 7.24.

Cell Viability Assay[2]

Cell Line: N. americanus
Concentration: 0-168.2 M (0-100 µg/mL)
Incubation Time: 72 h
Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
In Vivo

Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
Clinical Trial
Molecular Weight

594.68

Formula

C34H30N2O6S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.CN5CCCN=C5/C=C/C6=CC=CS6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (35.03 mM; ultrasonic and warming and heat to 70°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6816 mL 8.4079 mL 16.8158 mL
5 mM 0.3363 mL 1.6816 mL 3.3632 mL
10 mM 0.1682 mL 0.8408 mL 1.6816 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pyrantel pamoate
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