1. Anti-infection
  2. Parasite
    Antibiotic
  3. Pyrantel pamoate

Pyrantel pamoate (Synonyms: Pyrantel embonate)

Cat. No.: HY-12640 Purity: 99.94%
Handling Instructions

Pyrantel pamoate (Pyrantel embonate), a tetrahydropyrimidine broad-spectrum anthelmintic, is a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel pamoate can elicit spastic muscle paralysis in parasitic worms. Pyrantel pamoate can be used for the research of astrointestinal nematodes infections.

For research use only. We do not sell to patients.

Pyrantel pamoate Chemical Structure

Pyrantel pamoate Chemical Structure

CAS No. : 22204-24-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Description

Pyrantel pamoate (Pyrantel embonate), a tetrahydropyrimidine broad-spectrum anthelmintic, is a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel pamoate can elicit spastic muscle paralysis in parasitic worms. Pyrantel pamoate can be used for the research of astrointestinal nematodes infections[1][2][3].

In Vitro

Pyrantel induces Ascaris suum muscle contraction, with a pEC50 of 7.24[1].
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle[1].
Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum, Necator americanus and Trichuris muris on the third-stage larvae (IC50s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC50s=>100, 7.6, and 34.1 µg/mL, respectively)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

594.68

Formula

C₃₄H₃₀N₂O₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6816 mL 8.4079 mL 16.8158 mL
5 mM 0.3363 mL 1.6816 mL 3.3632 mL
10 mM 0.1682 mL 0.8408 mL 1.6816 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Pyrantel pamoate
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HY-12640
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