130-85-8
130-85-8
Chemical Structure
Pamoic acid
Synonym(s): Embonic acid
- CAS No.: 130-85-8
- Formula:C23H16O6
- Molecular Weight:388.38
IUPAC Name: 4,4'-methylenebis(3-hydroxy-2-naphthoic acid)
InChIKey: WLJNZVDCPSBLRP-UHFFFAOYSA-N
SMILES: OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4
Biological Activity: Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].
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Pamoic acid | 99.69% | Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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Pamoic acid (Standard) | ≥98% | Pamoic acid (Standard) is the analytical standard of Pamoic acid. This product is intended for research and analytical applications. Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-W010907Pamoic acid disodium -
Similarity Score 0.62
HY-W265961Squoxin -
Similarity Score 0.61
HY-W587022Chrysene-6,12-dicarboxylic acid -
Similarity Score 0.61
HY-W1049910Tetracene-5,12-dicarboxylic acid -
Similarity Score 0.60
HY-W1124214,4'-(Naphthalene-1,4-diyl)bis(2-hydroxybenzoic acid) -
Similarity Score 0.58
HY-W1130174,4'-(Anthracene-9,10-diyl)bis(2-hydroxybenzoicacid) -
Similarity Score 0.57
HY-W5868735-(10-Carboxy-9-anthracenyl)-1,3-benzenedicarboxylic acid -
Similarity Score 0.57
![[1,1'-Binaphthalene]-4,4'-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w094767.gif)
HY-W094767[1,1'-Binaphthalene]-4,4'-dicarboxylic acid -
Similarity Score 0.57
HY-W543695Anthracene-1,5-dicarboxylicacid -
Explore the MedChemAI to find more analogs
![[1,1'-Binaphthalene]-4,4'-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w094767.gif)
References
- [1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [Content Brief]
- [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. [Content Brief]
