130-85-8
130-85-8
Chemical Structure
Pamoic acid
Synonym(s): Embonic acid
- CAS No.: 130-85-8
- Formula:C23H16O6
- Molecular Weight:388.38
IUPAC Name: 4,4'-methylenebis(3-hydroxy-2-naphthoic acid)
InChIKey: WLJNZVDCPSBLRP-UHFFFAOYSA-N
SMILES: OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4
Biological Activity: Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].
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Pamoic acid | 99.69% | Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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Pamoic acid (Standard) | ≥98% | Pamoic acid (Standard) is the analytical standard of Pamoic acid. This product is intended for research and analytical applications. Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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References
- [1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [Content Brief]
- [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. [Content Brief]
